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==Neutrophil Novel Functional Model== | |||
Novel interactions of neutrophils with other immune cells. | |||
* '''A''' - Neutrophils (PMN) accumulate in the splenic marginal zone upon microbial challenge and facilitate the antibody production and maturation of marginal zone B cells (MZB) in response to T cell–independent (TI) antigens. | |||
* '''B''' - Neutrophils participate in a vicious cycle during autoimmune disease (e.g., SLE) pathogenesis by releasing NETs that trigger pDCs to release IFN-α, which then promotes antibody production by B cells (B). | |||
* '''C''' - Neutrophils may directly present antigens to T cells (T) and they also activate DCs and deliver antigens to them. | |||
* '''D''' - Neutrophils and DCs jointly activate NK cells (NK). | |||
Figure 2. http://jem.rupress.org/content/210/7/1283/F2.large.jpg | |||
{{Neutrophil model links}} | |||
===Reference=== | |||
<pubmed>23825232</pubmed>| [http://jem.rupress.org/content/210/7/1283.long J Exp Med.] | |||
====Copyright==== | |||
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). | |||
Figure 2. http://jem.rupress.org/content/210/7/1283/F2.large.jpg PMID label added. | |||
[[Category:Blood]][[Category:Immunity]][[CategoryCartoon]] | |||
Revision as of 08:57, 6 March 2015
Neutrophil Novel Functional Model
Novel interactions of neutrophils with other immune cells.
- A - Neutrophils (PMN) accumulate in the splenic marginal zone upon microbial challenge and facilitate the antibody production and maturation of marginal zone B cells (MZB) in response to T cell–independent (TI) antigens.
- B - Neutrophils participate in a vicious cycle during autoimmune disease (e.g., SLE) pathogenesis by releasing NETs that trigger pDCs to release IFN-α, which then promotes antibody production by B cells (B).
- C - Neutrophils may directly present antigens to T cells (T) and they also activate DCs and deliver antigens to them.
- D - Neutrophils and DCs jointly activate NK cells (NK).
- Immune Links: Neutrophil classical model | Neutrophil novel model | image - neutrophil histology | Immune System Development
Reference
<pubmed>23825232</pubmed>| J Exp Med.
Copyright
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
Figure 2. http://jem.rupress.org/content/210/7/1283/F2.large.jpg PMID label added.CategoryCartoon
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