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* '''Arx''' - Aristaless-Related Homeobox, X-Linked [http://www.omim.org/entry/300382 OMIM 300382]
* '''Arx''' - Aristaless-Related Homeobox, X-Linked [http://www.omim.org/entry/300382 OMIM 300382]
** homeobox protein that belongs to the Aristaless-related subset of the paired (Prd) class of homeodomain proteins.
* '''Nkx2.2''' - NK2 Homeobox 2 [http://omim.org/entry/604612 OMIM 604612]
* '''Nkx2.2''' - NK2 Homeobox 2 [http://omim.org/entry/604612 OMIM 604612]
** homeobox (Hox) containing transcription factor contain a 60-amino acid evolutionarily conserved DNA-binding homeodomain.  
** homeobox (Hox) containing transcription factor contain a 60-amino acid evolutionarily conserved DNA-binding homeodomain.  
** homeobox protein that belongs to the Aristaless-related subset of the paired (Prd) class of homeodomain proteins.
* '''Pax4''' - Paired Box Gene 4 [http://omim.org/entry/167413 OMIM 167413]
* '''Pax4''' - Paired Box Gene 4 [http://omim.org/entry/167413 OMIM 167413]
** transcription factor containing a paired box domain.
** transcription factor containing a paired box domain.

Revision as of 08:52, 31 August 2014

Molecular Development of Endocrine Pancreas Cells

Model placing gastrin cells in the transcriptional hierarchy of endocrine cells in the pancreas.

Pancreatic G cells

  • similar to alpha cells in that it is dependent on Arx.
  • similar to epsilon cells in that both gastrin and ghrelin are frequently co-expressed with glucagon in the embryonic pancreas.


Links: Endocrine ancreas | Pax | Molecular Development
Factor Information
  • Pdx1 - Pancreas/Duodenum Homeobox Protein 1 OMIM 600733
    • transcription (transactivator) factor binds the TAAT element in the promoter region of target genes, mainly those involved in pancreas development.
  • Ngn3 - Neurogenin3 OMIM 604882
    • basic helix-loop-helix transcription factor involved in the determination of neural precursor cells in the neuroectoderm.
  • NeuroD1 - Neurogenic Differentiation 1 OMIM 601724
    • a basic helix-loop-helix (bHLH) protein that acts as a transcription factors involved in determining cell type during development.
  • Arx - Aristaless-Related Homeobox, X-Linked OMIM 300382
    • homeobox protein that belongs to the Aristaless-related subset of the paired (Prd) class of homeodomain proteins.
  • Nkx2.2 - NK2 Homeobox 2 OMIM 604612
    • homeobox (Hox) containing transcription factor contain a 60-amino acid evolutionarily conserved DNA-binding homeodomain.
  • Pax4 - Paired Box Gene 4 OMIM 167413
    • transcription factor containing a paired box domain.
  • Pax6 Paired Box Gene 6 OMIM 607108
    • transcription factor containing a paired box domain.


References

<pubmed>23940571</pubmed>| PLoS One.

Copyright

© 2013 Suissa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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