Bone Development: Difference between revisions
From Embryology
| Line 38: | Line 38: | ||
== Other Textbooks == | == Other Textbooks == | ||
* '''Anatomy of the Human Body''' (H. Gray, 1918.)[http://www.bartleby.com/107/18.html Osteology] | * '''Anatomy of the Human Body''' (H. Gray, 1918.) historical anatomy text [http://www.bartleby.com/107/18.html Osteology] | ||
* '''Molecular Biology of the Cell'''[http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mboc4.section.4177#4187 Bone Is Continually Remodeled by the Cells Within It][http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mboc4.figgrp.4191 Image: Figure 22-52. Deposition of bone matrix by osteoblasts.][http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mboc4.figgrp.4196 Image: Figure 22-56. The development of a long bone.] | * '''Molecular Biology of the Cell'''[http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mboc4.section.4177#4187 Bone Is Continually Remodeled by the Cells Within It][http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mboc4.figgrp.4191 Image: Figure 22-52. Deposition of bone matrix by osteoblasts.][http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mboc4.figgrp.4196 Image: Figure 22-56. The development of a long bone.] | ||
* '''Molecular Cell Biology'''[http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mcb.section.6542#6553 Mutations in Collagen Reveal Aspects of Its Structure and Biosynthesis] | * '''Molecular Cell Biology'''[http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mcb.section.6542#6553 Mutations in Collagen Reveal Aspects of Its Structure and Biosynthesis] | ||
Revision as of 10:56, 21 September 2009
Introduction
Textbook
Histology and Cell Biology: An Introduction to Pathology, A.L. Kierszenbaum, 2002 - Connective Tissue, Chapter 4 pp118-129; Osteogenesis, Chapter 5 pp131-145
Haversian Systems
- also called osteons
- Volkmann's canals
Lamellae
- concentric
- interstitial
- circumferential
Cells
- osteocytes
- canaliculi
Bone Cells
Osteocytes
- mature bone-forming cells embedded in bone matrix
- derive from osteogenic stem cells forming Osteoblasts
- line surface of bone, secrete organic matrix of bone (osteoid), converted into osteocytes when become embedded in matrix (which calcifies soon after deposition) (Google- osteoblast images)
Osteoclasts
- bone-resorbing multinucleated macrophage-like cells, seal a small segment of extracellular space (between plasma membrane and bone surface), HCl secreted into this space by osteoclasts dissolves calcium phosphate crystals (give bone rigidity and strength) (Google- osteoclast images)
- do not mistake for megakaryocytes, found in bone marrow not associated with bone matrix.
Bone Matrix
The bone matrix has 2 major components. Organic portion composed of mainly collagen Type 1 (about 95%) and amorphous ground substance. Inorganic portion (50% dry weight of the matrix) composed of hydroxyapatite crystals, calcium, phosphorus, bicarbonate, nitrate, Mg, K, Na. (Google- bone matrix images)
Links
- Original class notes
- UNSW Virtual Slidebox Virtual Slidebox Phase 1
- Virtual Slidebox of Histology (USA) Skeletal system
Other Textbooks
- Anatomy of the Human Body (H. Gray, 1918.) historical anatomy text Osteology
- Molecular Biology of the CellBone Is Continually Remodeled by the Cells Within ItImage: Figure 22-52. Deposition of bone matrix by osteoblasts.Image: Figure 22-56. The development of a long bone.
- Molecular Cell BiologyMutations in Collagen Reveal Aspects of Its Structure and Biosynthesis
- The Cell- A Molecular ApproachSteroid Hormones and the Steroid Receptor Superfamily
- Clinical Methods: The History, Physical, and Laboratory Examinations100. Alkaline Phosphatase and Gamma Glutamyltransferase
- Endocrinology: An Integrated Approach by Nussey, S.S. and Whitehead, S.A. Endocrinology: Definition and causes of osteoporosis
- Developmental Biology 6th ed. by Gilbert, Scott F. Aging: The Biology of Senescence
