Bone Development: Difference between revisions

Revision as of 10:56, 21 September 2009

Introduction

Textbook

Histology and Cell Biology: An Introduction to Pathology, A.L. Kierszenbaum, 2002 - Connective Tissue, Chapter 4 pp118-129; Osteogenesis, Chapter 5 pp131-145

Haversian Systems

also called osteons
Volkmann's canals

Lamellae

concentric
interstitial
circumferential

Cells

osteocytes
canaliculi

Bone Cells

Osteocytes

mature bone-forming cells embedded in bone matrix
derive from osteogenic stem cells forming Osteoblasts
line surface of bone, secrete organic matrix of bone (osteoid), converted into osteocytes when become embedded in matrix (which calcifies soon after deposition) (Google- osteoblast images)

Osteoclasts

bone-resorbing multinucleated macrophage-like cells, seal a small segment of extracellular space (between plasma membrane and bone surface), HCl secreted into this space by osteoclasts dissolves calcium phosphate crystals (give bone rigidity and strength) (Google- osteoclast images)
do not mistake for megakaryocytes, found in bone marrow not associated with bone matrix.

Bone Matrix

The bone matrix has 2 major components. Organic portion composed of mainly collagen Type 1 (about 95%) and amorphous ground substance. Inorganic portion (50% dry weight of the matrix) composed of hydroxyapatite crystals, calcium, phosphorus, bicarbonate, nitrate, Mg, K, Na. (Google- bone matrix images)

Links

Original class notes
UNSW Virtual Slidebox Virtual Slidebox Phase 1
Virtual Slidebox of Histology (USA) Skeletal system

Other Textbooks

Anatomy of the Human Body (H. Gray, 1918.)Osteology
Molecular Biology of the CellBone Is Continually Remodeled by the Cells Within It Image: Figure 22-52. Deposition of bone matrix by osteoblasts.Image: Figure 22-56. The development of a long bone.
Molecular Cell BiologyMutations in Collagen Reveal Aspects of Its Structure and Biosynthesis
The Cell- A Molecular ApproachSteroid Hormones and the Steroid Receptor Superfamily
Clinical Methods: The History, Physical, and Laboratory Examinations100. Alkaline Phosphatase and Gamma Glutamyltransferase
Endocrinology: An Integrated Approach by Nussey, S.S. and Whitehead, S.A. Endocrinology: Definition and causes of osteoporosis
Developmental Biology 6th ed. by Gilbert, Scott F. Aging: The Biology of Senescence

@@ Line 1: / Line 1: @@
 == Introduction ==
+=== Textbook ===
+'''Histology and Cell Biology: An Introduction to Pathology''', A.L. Kierszenbaum, 2002 - Connective Tissue, Chapter 4 pp118-129; Osteogenesis, Chapter 5 pp131-145
 ===Haversian Systems===
@@ Line 15: / Line 18: @@
 * osteocytes
 * canaliculi
+== Bone Cells ==
+===Osteocytes===
+* mature bone-forming cells embedded in bone matrix
+* derive from osteogenic stem cells forming '''Osteoblasts'''
+* line surface of bone, secrete organic matrix of bone (osteoid), converted into '''osteocytes''' when become embedded in matrix (which calcifies soon after deposition) ([http://images.google.com/images?rls=en-au&q=osteoblast Google- osteoblast images])
+===Osteoclasts===
+* bone-resorbing multinucleated macrophage-like cells, seal a small segment of extracellular space (between plasma membrane and bone surface), HCl secreted into this space by osteoclasts dissolves calcium phosphate crystals (give bone rigidity and strength) ([http://images.google.com/images?rls=en-au&q=osteoclast Google- osteoclast images])
+* do not mistake for megakaryocytes, found in bone marrow not associated with bone matrix.
+== Bone Matrix ==
+The bone matrix has 2 major components. Organic portion composed of mainly collagen Type 1 (about 95%) and amorphous ground substance. Inorganic portion (50% dry weight of the matrix) composed of hydroxyapatite crystals, calcium, phosphorus, bicarbonate, nitrate, Mg, K, Na. ([http://images.google.com/images?rls=en-au&q=bone%20matrix Google- bone matrix images])
+== Links ==
+* [http://cellbiology.med.unsw.edu.au/units/medicine/REbone.htm Original class notes]
+* UNSW Virtual Slidebox [http://web.med.unsw.edu.au/vslide/phase1/indexA1.asp Virtual Slidebox Phase 1]
+* Virtual Slidebox of Histology (USA)  [http://www.path.uiowa.edu/cgi-bin-pub/vs/fpx_browse.cgi?cat=o_skeletal&div=nlm Skeletal system]
+== Other Textbooks ==
+* '''Anatomy of the Human Body''' (H. Gray, 1918.)[http://www.bartleby.com/107/18.html Osteology]
+* '''Molecular Biology of the Cell'''[http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mboc4.section.4177#4187 Bone Is Continually Remodeled by the Cells Within It][http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mboc4.figgrp.4191 Image: Figure 22-52. Deposition of bone matrix by osteoblasts.][http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mboc4.figgrp.4196 Image: Figure 22-56. The development of a long bone.]
+* '''Molecular Cell Biology'''[http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=mcb.section.6542#6553 Mutations in Collagen Reveal Aspects of Its Structure and Biosynthesis]
+* '''The Cell- A Molecular Approach'''[http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=cooper.section.2199#2202 Steroid Hormones and the Steroid Receptor Superfamily]
+* '''Clinical Methods: The History, Physical, and Laboratory Examinations'''[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=cm.chapter.3148 100. Alkaline Phosphatase and Gamma Glutamyltransferase]
+* '''Endocrinology: An Integrated Approach''' by Nussey, S.S. and Whitehead, S.A. [http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=endocrin.box.936 Endocrinology: Definition and causes of osteoporosis]
+* '''Developmental Biology''' 6th ed. by Gilbert, Scott F. [http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?db=Books&rid=dbio.section.4388#4391 Aging: The Biology of Senescence]