File:Lymph node cartoon 02.jpg: Difference between revisions
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[[category:Blood]] |
Revision as of 07:34, 29 February 2012
Cell Trafficking into and out of Lymph Nodes
Lymphocytes and dendritic cells (DCs) enter lymph nodes by different routes.
Lymphocytes
- Most lymphocytes migrating to lymph nodes enter from the peripheral blood.
- All leukocyte types are found in the arteries of lymph nodes.
- Only lymphocytes can interact with and extravasate through high endothelial venules (HEVs) to migrate into the lymph node parenchyma.
- T and B cells (lymphocytes) subsequently segregate into the T-cell zones and B-cell zones.
Dendritic cells
- Dendritic cells (DCs) with small numbers of lymphocytes enter lymph nodes through the afferent lymphatics.
- then accumulate in the vicinity of high endothelial venules.
- high endothelial venules are surrounded by fibroblastic reticular cells (FRCs)
Fibroblastic reticular cells
- (FRCs) form channels (FRC conduits) that project from the subcapsular sinus into the T-cell zone.
- Some chemokines produced extranodally might reach HEVs through the FRC conduit.
See also Lymph node - high endothelial venule cartoon.
Legend
- B - B-cell zones
- DC - dendritic cells
- FRC - fibroblastic reticular cells
- HEV - high endothelial venules
- Lymph Node Cartoons: Detailed structure | Cartoon with Histology | Lymphocyte traffic | Simple structure | Simple node anatomy | Wiki node image | Internal structure | Mesenteric lymph node | Histology | Gallery | Lymph Node Development
Reference
<pubmed>15122201</pubmed>| Nat Rev Immunol.
Adapted by permission from Macmillan Publishers Ltd: Nat. Rev. Immunol.: 2004, 4(5);360-70, copyright (2004)
Licensee: Mark A Hill License Number: 2857291045727 Publication: Nature Reviews Immunology
Title: Lymphocyte trafficking across high endothelial venules: dogmas and enigmas Type Of Use: post on the internet
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