File:Mouse eye TGF-beta model.jpg: Difference between revisions
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Summary of the TGFβ-dependent development of anterior and posterior ocular structures. | Summary of the TGFβ-dependent development of anterior and posterior ocular structures. | ||
(a) | (a) Neural crest-derived cells (NC, blue) contribute to structures of the anterior eye segment and the primary vitreous (PV). | ||
* TGFβ signaling is involved in the formation of the ciliary body (CB) and the trabecular meshwork (TM), and in control of PV growth. | |||
* Moreover, normal PV development and/or TGFβ signaling are important for correct retinal patterning. | |||
(b) In the cornea, prospective stromal keratocytes and endothelial cells are of | (b) In the cornea, prospective stromal keratocytes and endothelial cells are of neural crest origin. | ||
* Here, TGFβ signaling is needed for the expression of the transcription factors Foxc1 and Pitx2 and for normal differentiation of NC-derived cells into collagen-synthesizing stromal keratocytes. | |||
* Moreover, in forming corneal endothelial cells (and in the TM), expression of Foxc1 and cell survival requires TGFβ signalling. | |||
Figure 9. http://jbiol.com/content/4/3/11/figure/F9 | Figure 9. http://jbiol.com/content/4/3/11/figure/F9 |
Revision as of 18:34, 30 August 2011
Mouse Eye TGF-beta Model
Summary of the TGFβ-dependent development of anterior and posterior ocular structures.
(a) Neural crest-derived cells (NC, blue) contribute to structures of the anterior eye segment and the primary vitreous (PV).
- TGFβ signaling is involved in the formation of the ciliary body (CB) and the trabecular meshwork (TM), and in control of PV growth.
- Moreover, normal PV development and/or TGFβ signaling are important for correct retinal patterning.
(b) In the cornea, prospective stromal keratocytes and endothelial cells are of neural crest origin.
- Here, TGFβ signaling is needed for the expression of the transcription factors Foxc1 and Pitx2 and for normal differentiation of NC-derived cells into collagen-synthesizing stromal keratocytes.
- Moreover, in forming corneal endothelial cells (and in the TM), expression of Foxc1 and cell survival requires TGFβ signalling.
Figure 9. http://jbiol.com/content/4/3/11/figure/F9
Reference
<pubmed>16403239</pubmed>| J Biol.
Ittner et al. Journal of Biology 2005 4:11 doi:10.1186/jbiol29
© 2005 Ittner et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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