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===Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo=== | |||
Dev Growth Differ. 2011 Jul 15. doi: 10.1111/j.1440-169X.2011.01292.x. [Epub ahead of print] | |||
Tanaka SS, Kojima Y, Yamaguchi YL, Nishinakamura R, Tam PP. | |||
Source | |||
Department of Kidney Development, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan Embryology Unit, Children's Medical Research Institute (CMRI), Westmead, NSW, Australia Global COE "Cell Fate Regulation Research and Education Unit", Kumamoto University, Kumamoto, Japan Sydney Medical School, The University of Sydney, Sydney, NSW, Australia. | |||
Abstract | |||
WNT signaling activity is involved in the regulation of many cellular functions, including proliferation, migration, cell fate specification, maintenance of pluripotency and induction of tumorigenicity. Here we summarize recent progress towards understanding the regulation of canonical WNT/β-catenin signaling activity through feedback regulatory loops involving the ligands, agonists and antagonists, the availability of intracellular pools of active β-catenin and the cross-regulation of the WNT activity by β-catenin independent pathway. We also review recent findings on the role of WNT/β-catenin signaling in tissue lineage differentiation during embryogenesis and the maintenance and self renewal of embryo-derived stem cells in vitro. | |||
© 2011 The Authors. Development,Growth & Differentiation © 2011 Japanese Society of Developmental Biologists. | |||
PMID 21762130 | |||
Revision as of 19:13, 5 September 2011
Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo
Dev Growth Differ. 2011 Jul 15. doi: 10.1111/j.1440-169X.2011.01292.x. [Epub ahead of print]
Tanaka SS, Kojima Y, Yamaguchi YL, Nishinakamura R, Tam PP. Source Department of Kidney Development, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan Embryology Unit, Children's Medical Research Institute (CMRI), Westmead, NSW, Australia Global COE "Cell Fate Regulation Research and Education Unit", Kumamoto University, Kumamoto, Japan Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.
Abstract
WNT signaling activity is involved in the regulation of many cellular functions, including proliferation, migration, cell fate specification, maintenance of pluripotency and induction of tumorigenicity. Here we summarize recent progress towards understanding the regulation of canonical WNT/β-catenin signaling activity through feedback regulatory loops involving the ligands, agonists and antagonists, the availability of intracellular pools of active β-catenin and the cross-regulation of the WNT activity by β-catenin independent pathway. We also review recent findings on the role of WNT/β-catenin signaling in tissue lineage differentiation during embryogenesis and the maintenance and self renewal of embryo-derived stem cells in vitro.
© 2011 The Authors. Development,Growth & Differentiation © 2011 Japanese Society of Developmental Biologists.
PMID 21762130
