Talk:Developmental Signals - Sox: Difference between revisions
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PMID: 18351289 [PubMed - indexed for MEDLINE] | PMID: 18351289 [PubMed - indexed for MEDLINE] | ||
===SoxE proteins are differentially required in mouse adrenal gland development=== | |||
Mol Biol Cell. 2008 Apr;19(4):1575-86. Epub 2008 Feb 13. | |||
Reiprich S, Stolt CC, Schreiner S, Parlato R, Wegner M. | |||
Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany. | |||
Abstract | |||
Sry-box (Sox)8, Sox9, and Sox10 are all strongly expressed in the neural crest. Here, we studied the influence of these closely related transcription factors on the developing adrenal medulla as one prominent neural crest derivative. Whereas Sox9 was not expressed, both Sox8 and Sox10 occurred widely in neural crest cells migrating to the adrenal gland and in the gland itself, and they were down-regulated in cells expressing catecholaminergic traits. Sox10-deficient mice lacked an adrenal medulla. The adrenal anlage was never colonized by neural crest cells, which failed to specify properly at the dorsal aorta and died apoptotically during migration. Furthermore, mutant neural crest cells did not express Sox8. Strong adrenal phenotypes were also observed when the Sox10 dimerization domain was inactivated or when a transactivation domain in the central portion was deleted. Sox8 in contrast had only minimal influence on adrenal gland development. Phenotypic consequences became only visible in Sox8-deficient mice upon additional deletion of one Sox10 allele. Replacement of Sox10 by Sox8, however, led to significant rescue of the adrenal medulla, indicating that functional differences between the two related Sox proteins contribute less to the different adrenal phenotypes of the null mutants than dependence of Sox8 expression on Sox10. | |||
PMID: 18272785 | |||
===Back to basics: Sox genes=== | ===Back to basics: Sox genes=== | ||
Revision as of 16:49, 11 November 2010
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080623/?tool=pubmed
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Wegner M. Int J Biochem Cell Biol. 2010 Mar;42(3):381-90. Epub 2009 Jul 22. Review. PMID: 19631281 [PubMed - indexed for MEDLINE]
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Chew LJ, Gallo V. J Neurosci Res. 2009 Nov 15;87(15):3277-87. Review. PMID: 19437544 [PubMed - indexed for MEDLINE]
Control of chondrogenesis by the transcription factor Sox9
Akiyama H. Mod Rheumatol. 2008;18(3):213-9. Epub 2008 Mar 20. Review. PMID: 18351289 [PubMed - indexed for MEDLINE]
SoxE proteins are differentially required in mouse adrenal gland development
Mol Biol Cell. 2008 Apr;19(4):1575-86. Epub 2008 Feb 13.
Reiprich S, Stolt CC, Schreiner S, Parlato R, Wegner M.
Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany. Abstract Sry-box (Sox)8, Sox9, and Sox10 are all strongly expressed in the neural crest. Here, we studied the influence of these closely related transcription factors on the developing adrenal medulla as one prominent neural crest derivative. Whereas Sox9 was not expressed, both Sox8 and Sox10 occurred widely in neural crest cells migrating to the adrenal gland and in the gland itself, and they were down-regulated in cells expressing catecholaminergic traits. Sox10-deficient mice lacked an adrenal medulla. The adrenal anlage was never colonized by neural crest cells, which failed to specify properly at the dorsal aorta and died apoptotically during migration. Furthermore, mutant neural crest cells did not express Sox8. Strong adrenal phenotypes were also observed when the Sox10 dimerization domain was inactivated or when a transactivation domain in the central portion was deleted. Sox8 in contrast had only minimal influence on adrenal gland development. Phenotypic consequences became only visible in Sox8-deficient mice upon additional deletion of one Sox10 allele. Replacement of Sox10 by Sox8, however, led to significant rescue of the adrenal medulla, indicating that functional differences between the two related Sox proteins contribute less to the different adrenal phenotypes of the null mutants than dependence of Sox8 expression on Sox10.
PMID: 18272785
Back to basics: Sox genes
Kiefer JC. Dev Dyn. 2007 Aug;236(8):2356-66. Review. PMID: 17584862
