Template:Second-generation BTKi table: Difference between revisions
From Embryology
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|+ '''Novel BTK Inhibitors for CCL Treatment''' | |+ '''Novel BTK Inhibitors for CCL Treatment''' | ||
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! BTK inhibitor | ! width=150px|BTK inhibitor | ||
! BTK binding mechanism | ! BTK binding mechanism | ||
! Selectivity for BTK | ! Selectivity for BTK | ||
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| I | | I | ||
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| | | colspan=5|Table data {{#pmid:31028669|PMID31028669}} | ||
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Revision as of 14:01, 30 April 2019
BTK inhibitor | BTK binding mechanism | Selectivity for BTK | Relevant non-BTK targets | Phase of clinical development |
---|---|---|---|---|
Acalabrutinib | Covalent, irreversible | High | N/A | II/III |
Zanubrutinib | Covalent, irreversible | Moderate | N/A | II/III |
Tirabrutinib | Covalent, irreversible | High | N/A | I/II |
Vecabrutinib | Non-covalent, reversible | Moderate | interleukin-2-inducible (ITK) | I/II |
LOXO-305 | Non-covalent, reversible | High | N/A | I |
ARQ-531 | Non-covalent, reversible | Low | Lck/Yes novel tyrosine kinase (LYN), mitogen-activated protein kinase kinase 1 (MEK1) | I |
Table data [1] |