Talk:Oocyte Development

How eggs arrest at metaphase II: MPF stabilisation plus APC/C inhibition equals Cytostatic Factor http://www.celldiv.com/content/2/1/4

Balbiani body

• (Henneguy, 1887) is a cytoplasmic structure present in young immature oocytes in mammals and many other species
• transient structure composed of a large number of mitochondria, Golgi complexes, endoplasmic reticulum.
• ill-defined electron-dense granulofibrillar material that congregates at a perinuclear location
• as the oocyte matures it moves to a peripheral location in the oocyte cortex (in some species corresponding to the future vegetal pole) and disperses (reviewed by Kloc et al., 2004).

Function

• in some species contribute to the assembly and transportation of the germ plasm determinants to the cortex of the mature oocyte
• In mammals ( “inductive”, “regulative” or “epigenetic” mode of germ cell formation) do not have germ plasm determinants, the function remains largely obscure may include
  • the controlled amplification of mitochondria or the creation of an asymmetry or polarity in the oocyte.

Reference: http://www.hh.um.es/pdf/Vol_25/25_2/de-Sousa-Lopes-25-267-276-2010.pdf

Henneguy F. (1887). Note sur la vesicle de Balbiani. C. R. Hebd. Seances Soc. Biol. Ses. Fil. 39, 69.

Kloc M., Bilinski S. and Etkin L.D. (2004). The Balbiani body and germ cell determinants: 150 years later. Curr. Top. Dev. Biol. 59, 1-36.

References

Egg coat proteins activate calcium entry into mouse sperm via CATSPER channels

Xia J, Ren D. Biol Reprod. 2009 Jun;80(6):1092-8. Epub 2009 Feb 11. PMID: 19211808

ZP2 and ZP3 traffic independently within oocytes prior to assembly into the extracellular zona pellucida

Hoodbhoy T, Avilés M, Baibakov B, Epifano O, Jiménez-Movilla M, Gauthier L, Dean J. Mol Cell Biol. 2006 Nov;26(21):7991-8. PMID: 17047254