File:Human cochlea fetal development cartoon.jpg: Difference between revisions
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==Human cochlea fetal development cartoon== | ==Human cochlea fetal development cartoon== | ||
Schematic diagram of neurosensory development in the basal turn of the human fetal cochlea. | |||
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* '''Week 10''' (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium. | |||
* '''Week 11''' (W11) - Penetration starts prior to hair cell differentiation. At W12, the first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs. | |||
* '''Week 14''' (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2. | |||
* '''Week 20''' (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites. | |||
| Abbreviations | |||
* SGN - spiral ganglion neuron | |||
* IHC - inner hair cell | |||
* O1 - first row of outer hair cells | |||
* O2 - second row of outer hair cells | |||
* O3 - third row of outer hair cells | |||
* OHC - outer hair cell. | |||
|} | |||
:'''Links:''' [[Hearing_-_Inner_Ear_Development|Inner Ear Development]] | |||
===Reference=== | ===Reference=== | ||
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This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ||
1749-8104-8-20-9.jpg | Figure 9. 1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20 doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling. | ||
[[Category:Human]] [[Category:Fetal]] [[Category:Hearing]] [[Category:Inner Ear]] |
Revision as of 11:49, 29 June 2014
Human cochlea fetal development cartoon
Schematic diagram of neurosensory development in the basal turn of the human fetal cochlea.
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Abbreviations
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- Links: Inner Ear Development
Reference
<pubmed>24131517</pubmed>| Neural Dev.
Copyright
© 2013 Locher et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Figure 9. 1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20 doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling.
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