Talk:2009 Lecture 22: Difference between revisions
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==Neural Background Reading== | ==Neural Background Reading== | ||
* Different timings of dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system http://www3.interscience.wiley.com/journal/122616509/abstract?CRETRY=1&SRETRY=0 | * Different timings of dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system http://www3.interscience.wiley.com/journal/122616509/abstract?CRETRY=1&SRETRY=0 | ||
:"MicroRNAs, processed by the RNAase III enzyme Dicer, are 22 nucleotide endogenous noncoding small RNAs. The function of Dicer in the mouse central nervous system (CNS) development is not well understood. Here, we show that specifically deleting Dicer expression in the CNS and in the cerebral cortex using two Cre lines results in reduced progenitor numbers, abnormal neuronal differentiation, and thinner cortical wall. Incomplete Dicer deletion during early embryonic stages contributes to normal development of early-born neurons in the cortex and motor neurons in the spinal cord. However, at late embryonic stages when Dicer is completely ablated in the CNS, the migration of late-born neurons in the cortex and oligodendrocyte precursor expansion and differentiation in the spinal cord are greatly affected. Our studies of different timings of Dicer deletion demonstrate the importance of the Dicer-mediated microRNA pathway in regulating distinct phases of neurogenesis and gliogenesis during the CNS development. " | :"MicroRNAs, processed by the RNAase III enzyme Dicer, are 22 nucleotide endogenous noncoding small RNAs. The function of Dicer in the mouse central nervous system (CNS) development is not well understood. Here, we show that specifically deleting Dicer expression in the CNS and in the cerebral cortex using two Cre lines results in reduced progenitor numbers, abnormal neuronal differentiation, and thinner cortical wall. Incomplete Dicer deletion during early embryonic stages contributes to normal development of early-born neurons in the cortex and motor neurons in the spinal cord. However, at late embryonic stages when Dicer is completely ablated in the CNS, the migration of late-born neurons in the cortex and oligodendrocyte precursor expansion and differentiation in the spinal cord are greatly affected. Our studies of different timings of Dicer deletion demonstrate the importance of the Dicer-mediated microRNA pathway in regulating distinct phases of neurogenesis and gliogenesis during the CNS development. " | ||
* Early fetal brain growth. Burn J, Birkbeck JA, Roberts DF. Hum Biol. 1975 Dec;47(4):511-22. No abstract available [http://www.ncbi.nlm.nih.gov/pubmed/1193577 PMID: 1193577] | |||
* Quantitative growth and development of human brain. Dobbing J, Sands J. Arch Dis Child. 1973 Oct;48(10):757-67. No abstract available. [http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=4796010 PMID: 4796010] | |||
Revision as of 14:55, 11 October 2009
Neural Background Reading
- Different timings of dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system http://www3.interscience.wiley.com/journal/122616509/abstract?CRETRY=1&SRETRY=0
- "MicroRNAs, processed by the RNAase III enzyme Dicer, are 22 nucleotide endogenous noncoding small RNAs. The function of Dicer in the mouse central nervous system (CNS) development is not well understood. Here, we show that specifically deleting Dicer expression in the CNS and in the cerebral cortex using two Cre lines results in reduced progenitor numbers, abnormal neuronal differentiation, and thinner cortical wall. Incomplete Dicer deletion during early embryonic stages contributes to normal development of early-born neurons in the cortex and motor neurons in the spinal cord. However, at late embryonic stages when Dicer is completely ablated in the CNS, the migration of late-born neurons in the cortex and oligodendrocyte precursor expansion and differentiation in the spinal cord are greatly affected. Our studies of different timings of Dicer deletion demonstrate the importance of the Dicer-mediated microRNA pathway in regulating distinct phases of neurogenesis and gliogenesis during the CNS development. "
- Early fetal brain growth. Burn J, Birkbeck JA, Roberts DF. Hum Biol. 1975 Dec;47(4):511-22. No abstract available PMID: 1193577
- Quantitative growth and development of human brain. Dobbing J, Sands J. Arch Dis Child. 1973 Oct;48(10):757-67. No abstract available. PMID: 4796010
