File:Aschheim-Zondek Test 1928.gif: Difference between revisions

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:'''Links:''' [[Pregnancy Test]] | [[Menstrual Cycle]] | [[Week 2]] | [[Mouse Development]] | [[Frog Development]]
:'''Links:'''   [[:File:Aschheim-Zondek_Test_1928small.gif|Small Animation]] | [[: File:Aschheim-Zondek_Test_1928.gif|Large Animation]] | [[Pregnancy Test]] | [[Menstrual Cycle]] | [[Week 2]] | [[Mouse Development]] | [[Frog Development]]





Revision as of 11:16, 15 November 2012

Aschheim-Zondek Test (1928)

The basis of the original historic Aschheim-Zondek[1] test developed in 1928 was to identify the changes in immature female mouse genital system by female human urine injected subcutaneously into these immature mice.

  • If the woman was pregnant - the presence of hormones (hCG) induced changes in the mouse genital tract physiologically similar to those produced by sex hormones.
    • follicle maturation, corpora heamorrhagicum and corpora lutea formation.
  • If the woman was not pregnant - there were no changes induced.

This early mouse test was later replaced with a similar, but simpler, urine test using the Xenopus frog.

Animation based upon original line drawings.[2]


Links: Small Animation | Large Animation | Pregnancy Test | Menstrual Cycle | Week 2 | Mouse Development | Frog Development


Reference

  1. Aschheim, S., and Zondek, B., Klin. Wschr., 7 8, 1401 (1928).
  2. <pubmed>20318243</pubmed>

File history

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current12:02, 15 November 2012Thumbnail for version as of 12:02, 15 November 2012449 × 600 (280 KB)Z8600021 (talk | contribs)added ovary histology
12:01, 15 November 2012Thumbnail for version as of 12:01, 15 November 2012449 × 600 (278 KB)Z8600021 (talk | contribs)added ovary histology
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