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1471-2121-12-29-8.jpg | ==Tunneling model of lymphatic vessel formation== | ||
The model is based on ultrastructural observations performed in in vitro and in vivo models of lymphangiogenesis. | |||
* '''A''' - LEC alignment. Elongated LEC migrate and extend long cytoplasmic protrusions. | |||
* '''B''' - Vacuolization and matrix degradation. The continuity of LEC lining is mediated by interdigitations (i). Vesicle invaginations lead to the formation of intracellular vacuoles (v) in the cytoplasm and in protrusions. Matrix degradation (d) occurs intracellularly and extracellularly generating space between cells. | |||
* '''C''' - Luminogenesis. The lumen (lu) is formed de novo in the intercellular space. The intracellular vacuoles coalesce (cv) and likely fuse with the cytoplasmic membrane to increase the lumen. | |||
===Reference=== | |||
<pubmed>21702933</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141733 PMC3141733] | [http://www.biomedcentral.com/1471-2121/12/29 BMC Cell Biol.] | |||
Detry et al. BMC Cell Biology 2011 12:29 doi:10.1186/1471-2121-12-29 | |||
© 2011 Detry et al; licensee BioMed Central Ltd. | |||
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||
Original file name: 1471-2121-12-29-8.jpg | |||
[[Category:Cardiovascular]] [[Category:Immune]] |
Latest revision as of 10:02, 5 February 2012
Tunneling model of lymphatic vessel formation
The model is based on ultrastructural observations performed in in vitro and in vivo models of lymphangiogenesis.
- A - LEC alignment. Elongated LEC migrate and extend long cytoplasmic protrusions.
- B - Vacuolization and matrix degradation. The continuity of LEC lining is mediated by interdigitations (i). Vesicle invaginations lead to the formation of intracellular vacuoles (v) in the cytoplasm and in protrusions. Matrix degradation (d) occurs intracellularly and extracellularly generating space between cells.
- C - Luminogenesis. The lumen (lu) is formed de novo in the intercellular space. The intracellular vacuoles coalesce (cv) and likely fuse with the cytoplasmic membrane to increase the lumen.
Reference
<pubmed>21702933</pubmed>| PMC3141733 | BMC Cell Biol.
Detry et al. BMC Cell Biology 2011 12:29 doi:10.1186/1471-2121-12-29
© 2011 Detry et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original file name: 1471-2121-12-29-8.jpg
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