Talk:Paper - On a normal human ovum not over 7.5 days of age: Difference between revisions

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Thirty-four fertilized human ova, good, bad and indifferent, recovered from 210 women of known fertility; a study of biologic wastage in early human pregnancy Hertig, A T ; Rock, J ; Adams, E C ; Menkin, M C Pediatrics, January 1959, Vol.23(1 Part 2), pp.202-11

ON A HUMAN BLASTULA RECOVERED FROM THE UTERINE CAVITY 4 DAYS AFTER OVULATION Hertig, T., A. ; Rock, T., J. Obstetrical & Gynecological Survey, 1946, Vol.1(5), p.611-612 [Peer Reviewed Journal]

()N A HUMAN BLASTULA RECOVERED FROM THE UTERINE CAVITY 4 DAYS AFTER OVULATION

A. T. HERTIG AND J. Rock

Anat. Rec., 94: 469, 1946

The specimen was recovered from a uterus removed surgically on the twenty-first day of a menstrual cycle previously ranging from 25 to 32 days duration.

Probable fertile coitus occurred 4:} days previously. Endometrium morphologically was characteristic of the eighteenth day, ovulation having occurred 4 days previously. The stigma of the recent corpus luteum was unhealed.

The free-lying blastula was obtained in Locke’s solution removed by pipette from the cavity of a submerged uterus opened completely at one side and partially across the fundus. The specimen was discovered with a binocular dissecting microscope using 10 diameters of magniﬁcation. Fresh, the specimen measured 190 x 150 micra but after ﬁxation in Bouin’s ﬂuid, begun 1 hour after removal of the uterus, it measured 175 x 124 micra. It was surrounded by a sticky, thick, transparent, refractile vitelline membrane which shrank during ﬁxation.

Following dehydration and embedding in celloidin-paraﬁine, 15 perfect serial sections of 6 micra each were obtained by Dr. Chester Heuser. Nine blastomeres of varying size and shape were present: 5 containing 1 nucleus each, 3 with 2 nuclei each and 1 with 3 nuclei. Three of the single-nucleated blastomeres are in varying stages of mitosis. A segmentation cavity is just beginning to form.

Because of the presence of multinucleated blastomeres the specimen is probably not normal, although no other human specimen is available for comparison.

Studies on the human corpus luteum. I. Observations on the ultrastructure of development and regression of the luteal cells during the menstrual cycle Adams, E C ; Hertig, A T The Journal of cell biology, June 1969, Vol.41(3), pp.696-715 [Peer Reviewed Journal]

Studies on the human corpus luteum. II. Observations on the ultrastructure of luteal cells during pregnancy Adams, E C ; Hertig, A T The Journal of cell biology, June 1969, Vol.41(3), pp.716-35 [Peer Reviewed Journal]

The primary human oocyte: Some observations on the fine structure of Balbiani's vitelline body and the origin of the annulate lamellae Hertig, Arthur T. American Journal of Anatomy, January 1968, Vol.122(1), pp.107-137

The Histogenesis of Granulosa and Theca Cell Tumors of the Human Ovary Mckay, G., Donald ; Hertig, T., Arthur ; Hickey, F., William Obstetrics & Gynecology, 1953, Vol.1(2), p.125-136 [Peer Reviewed Journal]

Human trophoblast in tissue culture. SOMA, H. ; EHRMANN, R.L. ; HERTIG, A.T. Obstetrics and gynecology, December 1961, Vol.18, pp.704-718 [Peer Reviewed Journal] peer_reviewed

Development of the human ovary--a study using histochemical technics. PINKERTON, J.H. ; McKAY, D.G. ; ADAMS, E.C. ; HERTIG, A.T. Obstetrics and gynecology, August 1961, Vol.18, pp.152-181 [Peer Reviewed Journal] peer_reviewed

Histochemical Observations on the Human Placenta Mckay, G., Donald ; Hertig, T., Arthur ; Adams, C., Eleanor ; Richardson, V., Margaret Obstetrics & Gynecology, 1958, Vol.12(1), p.1-36 [Peer Reviewed Journal]

The adult human ovary: a histochemical study. MCKAY, D.G. ; PINKERTON, J.H. ; HERTIG, A.T. ; DANZIGER, S. Obstetrics and gynecology, July 1961, Vol.18, pp.13-39 [Peer Reviewed Journal] peer_reviewed

Histochemical aspects of hydatidiform mole and choriocarcinoma. BUR, G.E. ; HERTIG, A.T. ; McKAYDG, E.C. ; ADAMS, E.C. Obstetrics and gynecology, February 1962, Vol.19, pp.156-182 [Peer Reviewed Journal] peer_reviewed

Regression of Trophoblast: I. Hydatidiform mole; a case of unusual features, possibly metastasis and regression; review of literature Bardawil, A., Wadi ; Hertig, T., Arthur ; Velardo, T., Joseph Obstetrics & Gynecology, 1957, Vol.10(6), p.614-625 [Peer Reviewed Journal]

Historical events in pathology. A pathologist looks at normal and abnormal trophoblast Hertig, A T The American journal of pathology, October 1978, Vol.93(1), pp.136 [Peer Reviewed Journal]

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-On a normal ovum of approximately 9 to 10 days of age. Arthur T. HERTIG and John ROCK, Free Hospital for Women, Brookline, Mass., Departments of Pathology, Obstetrics and Gynecology, Harvard Medical School, and Department of Embryology, Carnegie Institution of Washington.
+Thirty-four fertilized human ova, good, bad and indifferent, recovered from 210 women of known fertility; a study of biologic wastage in early human pregnancy
-The ovum (Carnegie 8215) was discovered in a uterus removed surgically on the fifty-sixth day of .the menstrual cycle (periodicity infrequent and irregular). Endometrial histology indi- cated a typical twenty-fourth day secretory phase with ovulation having occurred approximately 10 days before.
+Hertig, A T ; Rock, J ; Adams, E C ; Menkin, M C
-The implantation site was posterior, at the corm opposite the ovary of origin, and without visible vascular response. It appeared as a slight elevated area measuring 0.57 mm. in diameter surmounted by a tiny 0.115 X 0.154 mm. area of ulceration.
+Pediatrics, January 1959, Vol.23(1 Part 2), pp.202-11
-The chorion measures 0.207 X 0.498 X 0.525 mm.; the chorionic cavity 0.100 X 0.210 X 0.228 mm.; the embryo 0.050 X 0.052 X 0.084 mm. and the amniotic cavity 0.022 X 0.048 X 0.050 mm. The ovum is nearly completely embedded within a rather markedly vascular but relatively ischemic endometrium showing only minimal predecidual response. The trophoblast, indifferent at the abembryonic pole, possesses elsewhere an inner cytotrophoblast and an outer, lacuna-
-riddled, blood-filled syncytiotrophoblast.
-The nearly globular, normally situated, bilaminar germ disk shows early vacuolization of its
+ON A HUMAN BLASTULA RECOVERED FROM THE UTERINE CAVITY 4 DAYS AFTER OVULATION
-ectoderm. The amnion is well formed but still lightly attached to its parental trophoblast. Mesoblast formation is active with development of the exocoelomic (Heuser’s) membrane. Angiogenesis is absent within the chorionic cavity. Focal accumulations of cytotrophoblast - primordia of chorionic villi - are beginning to appear.
+Hertig, T., A. ; Rock, T., J.
+Obstetrical & Gynecological Survey, 1946, Vol.1(5), p.611-612 [Peer Reviewed Journal]
+()N A HUMAN BLASTULA RECOVERED FROM THE UTERINE
+CAVITY 4 DAYS AFTER OVULATION
+A. T. HERTIG AND J. Rock
+Anat. Rec., 94: 469, 1946
+The specimen was recovered from a uterus removed surgically on the twenty-first day of a menstrual cycle previously ranging from 25 to 32 days duration.
+Probable fertile coitus occurred 4:} days previously. Endometrium morphologically was characteristic of the eighteenth day, ovulation having occurred 4
+days previously. The stigma of the recent corpus luteum was unhealed.
+The free-lying blastula was obtained in Locke’s solution removed by pipette from the cavity of a submerged uterus opened completely at one side and partially
+across the fundus. The specimen was discovered with a binocular dissecting
+microscope using 10 diameters of magniﬁcation. Fresh, the specimen measured
+x 150 micra but after ﬁxation in Bouin’s ﬂuid, begun 1 hour after removal of
+the uterus, it measured 175 x 124 micra. It was surrounded by a sticky, thick,
+transparent, refractile vitelline membrane which shrank during ﬁxation.
+Following dehydration and embedding in celloidin-paraﬁine, 15 perfect serial
+sections of 6 micra each were obtained by Dr. Chester Heuser. Nine blastomeres
+of varying size and shape were present: 5 containing 1 nucleus each, 3 with 2
+nuclei each and 1 with 3 nuclei. Three of the single-nucleated blastomeres are
+in varying stages of mitosis. A segmentation cavity is just beginning to form.
+Because of the presence of multinucleated blastomeres the specimen is probably
+not normal, although no other human specimen is available for comparison.
+Studies on the human corpus luteum. I. Observations on the ultrastructure of development and regression of the luteal cells during the menstrual cycle
+Adams, E C ; Hertig, A T
+The Journal of cell biology, June 1969, Vol.41(3), pp.696-715 [Peer Reviewed Journal]
+Studies on the human corpus luteum. II. Observations on the ultrastructure of luteal cells during pregnancy
+Adams, E C ; Hertig, A T
+The Journal of cell biology, June 1969, Vol.41(3), pp.716-35 [Peer Reviewed Journal]
+The primary human oocyte: Some observations on the fine structure of Balbiani's vitelline body and the origin of the annulate lamellae
+Hertig, Arthur T.
+American Journal of Anatomy, January 1968, Vol.122(1), pp.107-137
+The Histogenesis of Granulosa and Theca Cell Tumors of the Human Ovary
+Mckay, G., Donald ; Hertig, T., Arthur ; Hickey, F., William
+Obstetrics & Gynecology, 1953, Vol.1(2), p.125-136 [Peer Reviewed Journal]
+Human trophoblast in tissue culture.
+SOMA, H. ; EHRMANN, R.L. ; HERTIG, A.T.
+Obstetrics and gynecology, December 1961, Vol.18, pp.704-718 [Peer Reviewed Journal]
+peer_reviewed
+Development of the human ovary--a study using histochemical technics.
+PINKERTON, J.H. ; McKAY, D.G. ; ADAMS, E.C. ; HERTIG, A.T.
+Obstetrics and gynecology, August 1961, Vol.18, pp.152-181 [Peer Reviewed Journal]
+peer_reviewed
+Histochemical Observations on the Human Placenta
+Mckay, G., Donald ; Hertig, T., Arthur ; Adams, C., Eleanor ; Richardson, V., Margaret
+Obstetrics & Gynecology, 1958, Vol.12(1), p.1-36 [Peer Reviewed Journal]
+The adult human ovary: a histochemical study.
+MCKAY, D.G. ; PINKERTON, J.H. ; HERTIG, A.T. ; DANZIGER, S.
+Obstetrics and gynecology, July 1961, Vol.18, pp.13-39 [Peer Reviewed Journal]
+peer_reviewed
+Histochemical aspects of hydatidiform mole and choriocarcinoma.
+BUR, G.E. ; HERTIG, A.T. ; McKAYDG, E.C. ; ADAMS, E.C.
+Obstetrics and gynecology, February 1962, Vol.19, pp.156-182 [Peer Reviewed Journal]
+peer_reviewed
+Regression of Trophoblast: I. Hydatidiform mole; a case of unusual features, possibly metastasis and regression; review of literature
+Bardawil, A., Wadi ; Hertig, T., Arthur ; Velardo, T., Joseph
+Obstetrics & Gynecology, 1957, Vol.10(6), p.614-625 [Peer Reviewed Journal]
+Historical events in pathology. A pathologist looks at normal and abnormal trophoblast
+Hertig, A T
+The American journal of pathology, October 1978, Vol.93(1), pp.136 [Peer Reviewed Journal]