Talk:SH Lecture - Lymphatic Structure and Organs

Pubmed Bookshelf

• Medical Microbiology Chapter 1Immunology Overview

Immunobiology

5th edition The Immune System in Health and Disease Charles A Janeway, Jr, Paul Travers, Mark Walport, and Mark J Shlomchik.

Contents

• Preface to the Fifth Edition
• Acknowledgments
• Icons Used Throughout the Book

Part I. An Introduction to Immunobiology and Innate Immunity

• Chapter 1. Basic Concepts in Immunology

** The components of the immune system
** Principles of innate and adaptive immunity
** The recognition and effector mechanisms of adaptive immunity
** Summary to Chapter 1
** General references

• Chapter 2. Innate Immunity

** The front line of host defense

• • The complement system and innate immunity
  • Receptors of the innate immune system
  • Induced innate responses to infection
  • Summary to Chapter 2
  • General references
  • Section references

Part II. The Recognition of Antigen

• Chapter 3. Antigen Recognition by B-cell and T-cell Receptors
  • The structure of a typical antibody molecule
  • The interaction of the antibody molecule with specific antigen
  • Antigen recognition by T cells
  • Summary to Chapter 3
  • General references
  • Section references
• Chapter 4. The Generation of Lymphocyte Antigen Receptors
  • The generation of diversity in immunoglobulins
  • T-cell receptor gene rearrangement
  • Structural variation in immunoglobulin constant regions
  • Summary to Chapter 4
  • General references
  • Section references
• Chapter 5. Antigen Presentation to T Lymphocytes

** The generation of T-cell receptor ligands

• • The major histocompatibility complex and its functions
  • Summary to Chapter 5
  • General references
  • Section references

Part III. The Development of Mature Lymphocyte Receptor Repertoires

• Chapter 6. Signaling Through Immune System Receptors

** General principles of transmembrane signaling

• • Antigen receptor structure and signaling pathways
  • Other signaling pathways that contribute to lymphocyte behavior
  • Summary to Chapter 6
  • General references
  • Section references
• Chapter 7. The Development and Survival of Lymphocytes

** Generation of lymphocytes in bone marrow and thymus

• • The rearrangement of antigen-receptor gene segments controls lymphocyte development
  • Interaction with self antigens selects some lymphocytes for survival but eliminates others
  • Survival and maturation of lymphocytes in peripheral lymphoid tissues
  • Summary to Chapter 7
  • General references
  • Section references

Part IV. The Adaptive Immune Response

• Chapter 8. T Cell-Mediated Immunity
  • The production of armed effector T cells
  • General properties of armed effector T cells
  • T cell-mediated cytotoxicity
  • Macrophage activation by armed CD4 TH1 cells
  • Summary to Chapter 8
  • General references
  • Section references
• Chapter 9. The Humoral Immune Response

** B-cell activation by armed helper T cells

• • The distribution and functions of immunoglobulin isotypes
  • The destruction of antibody-coated pathogens via Fc receptors
  • Summary to Chapter 9
  • General references
  • Section references
• Chapter 10. Adaptive Immunity to Infection
  • Infectious agents and how they cause disease
  • The course of the adaptive response to infection
  • The mucosal immune system
  • Immunological memory
  • Summary to Chapter 10
  • General references
  • Section references

Part V. The Immune System in Health and Disease

• Chapter 11. Failures of Host Defense Mechanisms
  • Pathogens have evolved various means of evading or subverting normal host defenses
  • Inherited immunodeficiency diseases
  • Acquired immune deficiency syndrome
  • Summary to Chapter 11
  • General references
  • Section references
• Chapter 12. Allergy and Hypersensitivity
  • The production of IgE
  • Effector mechanisms in allergic reactions
  • Hypersensitivity diseases
  • Summary to Chapter 12
  • General references
  • Section references
• Chapter 13. Autoimmunity and Transplantation
  • Autoimmune responses are directed against self antigens
  • Responses to alloantigens and transplant rejection
  • Self-tolerance and its loss
  • Summary to Chapter 13
  • General references
  • Section references
• Chapter 14. Manipulation of the Immune Response
  • Extrinsic regulation of unwanted immune responses
  • Using the immune response to attack tumors
  • Manipulating the immune response to fight infection
  • Summary to Chapter 14
  • General references
  • Section references
• Chapter 15. Afterword
  • Evolution of the innate immune system
  • Evolution of the adaptive immune response
  • The importance of immunological memory in fixing adaptive immunity in the genome
  • Future directions of research in immunobiology
  • Summary of the Afterword
• Appendices
  • Appendix I. Immunologists' Toolbox
  • Appendix II. CD Antigens
  • Appendix III. Cytokines and Their Receptors
  • Appendix IV. Chemokines and Their Receptors
  • Appendix V. Immunological Constants
• Biographies
• Glossary

• Molecular Biology of the Cell Lymphocytes and the Cellular Basis of Adaptive Immunity | The Adaptive Immune System | Innate Immunity

Search PubMed Databases immune system

2011

Start Time/End Time: 10am to 11am Monday 28 February 2011 Clancy Auditorium eMed Link to Learning Activity - Lymphatic organs histology

• UNSW Virtual Slide set http://vslides.unsw.edu.au/VirtualSlideV2.nsf/id/FA8942
• Blue Histology - Lymphoid Tissues I
• Blue Histology - Lymphoid Tissues II

Bookshelf links

old - http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A4419&rendertype=figure&id=A4423 MBoC Figure 24-3 Human lymphoid organs

new - http://www.ncbi.nlm.nih.gov/books/NBK26921/figure/A4423 MBoC Figure 24-3 Human lymphoid organs

Recent Research

Defining the quantitative limits of intravital two-photon lymphocyte tracking

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12401-6. Epub 2011 Jul 6.

Textor J, Peixoto A, Henrickson SE, Sinn M, von Andrian UH, Westermann J. Source Institute for Theoretical Computer Science, University of Lübeck, 23562 Lübeck, Germany. textor@tcs.uni-luebeck.de

Abstract

Two-photon microscopy has substantially advanced our understanding of cellular dynamics in the immune system. Cell migration can now be imaged in real time in the living animal. Strikingly, the migration of naive lymphocytes in secondary lymphoid tissue appears predominantly random. It is unclear, however, whether directed migration may escape detection in this random background. Using a combination of mathematical modeling and experimental data, we investigate the extent to which modern two-photon imaging can rule out biologically relevant directed migration. For naive T cells migrating in uninfected lymph nodes (LNs) at average 3D speeds of around 18 μm/min, we rule out uniform directed migration of more than 1.7 μm/min at the 95% confidence level, confirming that T cell migration is indeed mostly random on a timescale of minutes. To investigate whether this finding still holds for longer timescales, we use a 3D simulation of the naive T cell LN transit. A pure random walk predicts a transit time of around 16 h, which is in good agreement with experimental results. A directional bias of only 0.5 μm/min-less than 3% of the cell speed-would already accelerate the transit twofold. These results jointly strengthen the random walk analogy for naive T cell migration in LNs, but they also emphasize that very small deviations from random migration can still be important. Our methods are applicable to cells of any type and can be used to reanalyze existing datasets.

PMID 21734152

http://www.pnas.org/content/108/30/12401.full

Stromal cell contributions to the homeostasis and functionality of the immune system

Nat Rev Immunol. 2009 Sep;9(9):618-29. Epub 2009 Jul 31.

Mueller SN, Germain RN. Source Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010 Victoria, Australia. smue@unimelb.edu.au Abstract A defining characteristic of the immune system is the constant movement of many of its constituent cells through the secondary lymphoid tissues, mainly the spleen and lymph nodes, where crucial interactions that underlie homeostatic regulation, peripheral tolerance and the effective development of adaptive immune responses take place. What has only recently been recognized is the role that non-haematopoietic stromal elements have in many aspects of immune cell migration, activation and survival. In this Review, we summarize our current understanding of lymphoid compartment stromal cells, examine their possible heterogeneity, discuss how these cells contribute to immune homeostasis and the efficient initiation of adaptive immune responses, and highlight how targeting of these elements by some pathogens can influence the host immune response.

PMID 19644499

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785037

http://www.nature.com/nri/journal/v9/n9/abs/nri2588.html

http://www.microbiol.unimelb.edu.au/research/immunology/s_mueller.html

Lymphatic vessels: structure and function

Isr Med Assoc J. 2011 Dec;13(12):762-8.

Rovenská E, Rovenský J. Source National institute of Rheumatic Diseases, Piestany, Slovak Republik. rovensky.jozef@nurch.sk l ymphatic vessels are part of the lymphatic system. The ves- sels evolved phylogenetically only after it became necessary for multicellular organisms to remove fluids and proteins from tissue and return them to the bloodstream. In humans, the lymphatic system begins to develop between the sixth and seventh week of embryonic development, at a time when the cardiovascular system is already functioning.

PMID 22332449

http://www.ima.org.il/imaj/dynamic/web/ArtFromPubmed.asp?year=2011&month=12&page=762