Talk:2011 Group Project 11

Group 11: User:z3308965 | User:z3292953 | User:z3308968 | User:z3272325 | User:z3284061

Plagiarism

--Mark Hill 07:35, 30 September 2011 (EST) Currently all students originally assigned to each group are listed as equal authors/contributors to their project. If you have not contributed the content you had originally agreed to, nor participated in the group work process, then you should contact the course coordinator immediately and either discuss your contribution or request removal from the group author list. Remember that all student online contributions are recorded by date, time and the actual contributed content. A similar email reminder will be sent to all current students.

Please note the Universities Policy regarding Plagiarism

In particular this example:

"Claiming credit for a proportion of work contributed to a group assessment item that is greater than that actually contributed;"

Academic Misconduct carries penalties. If a student is found guilty of academic misconduct, the penalties include warnings, remedial educative action, being failed in an assignment or excluded from the University for two years.

2011 Projects: Turner Syndrome | DiGeorge Syndrome | Klinefelter's Syndrome | Huntington's Disease | Fragile X Syndrome | Tetralogy of Fallot | Angelman Syndrome | Friedreich's Ataxia | Williams-Beuren Syndrome | Duchenne Muscular Dystrolphy | Cleft Palate and Lip

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Hey guys,

Sorry I've been MIA this weekend, I'v been working and away all weekend. You guys are doing an amazing job!! I'll be hopefully finishing up the Glossary tomorrow. Also, I checked the discussion page earlier today and it was all good but its mostly all gone now just like the actual page.

--Elizabeth Wren 21:21, 9 October 2011 (EST)

Dear Team.

Here's the Genetic Configuration and Evironmental :)

with formatting and stuff. the only 2 things missing are: an image and maybe the flow chart( same as the table in here)

Genetic Configuration and Environmental factors SECTION:

The origin of Cleft lip/ palate genetic and environmental factors arose since 1940s. A number of studies have been composed to elucidate the ambiguity behind this embryonic abnormality. It is believed that these combined factors contribute to the increase of Cleft lip/ palate incidence. Some of the genes that have been identified to have a vital role in the development of CL/CP include;

Genetic Factors	environmental Factors.
Transforming Growth Factor α (TGFA)
	Smoking
Transforming Growth Factor β 3 ( TGF β3)
	Alcohol
Muscle segment homeobox 1 (MSX1)
	Diatery (Folic Acid)

Transforming Growth Factor α (TGFA) TGFA is regarded as one of the significant genes that have been studied extensively due to its relevance to the oral clefts. TGFA is a trans-membrane protein that is expressed at the medial edge epithelium (MEE) of fusing palatal shelves. The receptor of this gene, epidermal growth factor receptor (EGFR) is expressed on the defenerating MEE. In a study conducted on mice It was found that the deletion or alteration of this receptor contributed mostly to the facial medio-lateral defects and high occurance of cleft palate formation.

Transforming Growth Factor β 3 ( TGF β3)

Transforming Growth factor family consists of more than 30 ligands, which is believed to be involved in a numerous number of briological functions such as proliferation, differentiation, epithelium-mesenchymal transformation, and apoptosis. TFG β3 is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development. This protein was detected in the epithelial component of the vertical palatal shelf which peaks between 14-14.5 days, prior to the contact of the palatal shelves. Potential roles of the TGF β3 in cellular adhesion, and extracellular formation during the process of palate development have been demonstrated both in vivo and vitro. The alteration or mutation of this factor via smoking or other factors may result in the failure of epithelial cells during the development of palate to fuse together. Consequently, fetous is likely to develop cleft palate abnormality.

Muscle segment homeobox 1 (MSX1)

Muscle segment homeobox 1 (MSX1) is a protein which is encoded by MSX1 gene. The transcripts of this protein are found in several locations such as thyrotrope-deriv