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Model for Sequential Phases of Preplacodal Development

Late Blastula Stage

Bmp acts as a morphogen that specifies neural crest (NC) within a narrow but low range of signalling.
Higher levels of Bmp signaling establish the non-neural ectoderm as a broad zone of uncommitted cells with potential to form epidermal or preplacodal ectoderm (PPE).
Within the non neural ectoderm
- changing levels of Bmp do not distinguish preplacodal from epidermal potential.
- preplacodal competence factors are uniformly induced throughout this domain.
expression of tfap2a/c overlaps with the lateral edges of the neural plate where, perhaps in combination with neural markers, they cell-autonomously specify NC fate.

Late Gastrula Stage (9–10 hpf)

preplacodal ectoderm (PPE) fate is specified in competent cells near the neural-nonneural border by dorsally expressed Bmp antagonists, Fgf and Pdgf.
Complete attenuation of Bmp is required for PPE specification.

Relevant markers for each ectodermal domain are shown. Experiments carried out in zebrafish.

Links: Placodes

Original file name: Figure 8. Journal.pgen.1001133.g008.jpg (some text above modified from figure legend)

Reference

<pubmed>20885782</pubmed>| PLoS Genet.

© 2010 Kwon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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 ==Model for Sequential Phases of Preplacodal Development==
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 * Bmp acts as a morphogen that specifies neural crest (NC) within a narrow but low range of signalling.
 * Higher levels of Bmp signaling establish the non-neural ectoderm as a broad zone of uncommitted cells with potential to form epidermal or preplacodal ectoderm (PPE).