File:Preplacodal development model.jpg: Difference between revisions
From Embryology
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==Model for Sequential Phases of Preplacodal Development== | ==Model for Sequential Phases of Preplacodal Development== | ||
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| ''' | | '''Late Blastula Stage''' | ||
* Bmp acts as a morphogen that specifies neural crest (NC) within a narrow but low range of signalling. | * Bmp acts as a morphogen that specifies neural crest (NC) within a narrow but low range of signalling. | ||
* Higher levels of Bmp signaling establish the non-neural ectoderm as a broad zone of uncommitted cells with potential to form epidermal or preplacodal ectoderm (PPE). | * Higher levels of Bmp signaling establish the non-neural ectoderm as a broad zone of uncommitted cells with potential to form epidermal or preplacodal ectoderm (PPE). | ||
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* expression of tfap2a/c overlaps with the lateral edges of the neural plate where, perhaps in combination with neural markers, they cell-autonomously specify NC fate. | * expression of tfap2a/c overlaps with the lateral edges of the neural plate where, perhaps in combination with neural markers, they cell-autonomously specify NC fate. | ||
| valign="top"|''' | | valign="top"|'''Late Gastrula Stage''' (9–10 hpf) | ||
* preplacodal ectoderm (PPE) fate is specified in competent cells near the neural-nonneural border by dorsally expressed Bmp antagonists, Fgf and Pdgf. | * preplacodal ectoderm (PPE) fate is specified in competent cells near the neural-nonneural border by dorsally expressed Bmp antagonists, Fgf and Pdgf. | ||
* Complete attenuation of Bmp is required for PPE specification. | * Complete attenuation of Bmp is required for PPE specification. |
Revision as of 15:51, 4 October 2011
Model for Sequential Phases of Preplacodal Development
Late Blastula Stage
|
Late Gastrula Stage (9–10 hpf)
Relevant markers for each ectodermal domain are shown. Experiments carried out in zebrafish. |
- Links: Placodes
Original file name: Figure 8. Journal.pgen.1001133.g008.jpg (some text above modified from figure legend)
Reference
<pubmed>20885782</pubmed>| PLoS Genet.
© 2010 Kwon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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current | 15:43, 4 October 2011 | ![]() | 800 × 416 (41 KB) | S8600021 (talk | contribs) | ==Model for Sequential Phases of Preplacodal Development== During late blastula stage, Bmp acts as a morphogen that specifies neural crest (NC) within a narrow but low range of signaling, whereas higher levels of Bmp signaling establish the nonneural ect |
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