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==History== | ==History== | ||
Huntington's disease has existed since at least the seventeenth century and several physicians provided earlier descriptions of hereditary chorea but without much detail. In 1872, Huntington’s disease was first documented with great details by George Huntington in “On Chorea”.(link) Huntington’s disease was initially known as chorea, derived from the Greek word “khoreia” which means dancing in unison. (link: http://www.memidex.com/choreography+notational-system#etymology). | |||
George Huntington described the disease as “an heirloom from generations away back in the dim past” as he realized that HD was hereditary. This conclusion was reached when he observed that if one of the parents had the disease, the offspring will inevitably have the disease too. In his paper, “On Chorea”, he described: | |||
"Of its hereditary nature. When either or both the parents have shown manifestations of the disease ..., one or more of the offspring almost invariably suffer from the disease ... But if by any chance these children go through life without it, the thread is broken and the grandchildren and great-grandchildren of the original shakers may rest assured that they are free from the disease.".<ref><pubmed>11232352</pubmed></ref> | "Of its hereditary nature. When either or both the parents have shown manifestations of the disease ..., one or more of the offspring almost invariably suffer from the disease ... But if by any chance these children go through life without it, the thread is broken and the grandchildren and great-grandchildren of the original shakers may rest assured that they are free from the disease.".<ref><pubmed>11232352</pubmed></ref> | ||
Huntington thus was able to explain the precise pattern of inheritance of autosomal dominant disease years before the rediscovery by scientists of Mendelian inheritance. | |||
==Treatment== | ==Treatment== | ||
Revision as of 22:26, 31 August 2011
History
Huntington's disease has existed since at least the seventeenth century and several physicians provided earlier descriptions of hereditary chorea but without much detail. In 1872, Huntington’s disease was first documented with great details by George Huntington in “On Chorea”.(link) Huntington’s disease was initially known as chorea, derived from the Greek word “khoreia” which means dancing in unison. (link: http://www.memidex.com/choreography+notational-system#etymology). George Huntington described the disease as “an heirloom from generations away back in the dim past” as he realized that HD was hereditary. This conclusion was reached when he observed that if one of the parents had the disease, the offspring will inevitably have the disease too. In his paper, “On Chorea”, he described:
"Of its hereditary nature. When either or both the parents have shown manifestations of the disease ..., one or more of the offspring almost invariably suffer from the disease ... But if by any chance these children go through life without it, the thread is broken and the grandchildren and great-grandchildren of the original shakers may rest assured that they are free from the disease.".[1]
Huntington thus was able to explain the precise pattern of inheritance of autosomal dominant disease years before the rediscovery by scientists of Mendelian inheritance.
Treatment
There is no cure for Huntington's disease. Similar to AIDS, only the symptoms can be treated to slow down the progression of the disease.
Medications
- Movement disorders
- Psychiatric disorders
Therapies
- Psychotherapy
- Speech Therapy
- Physical Therapy
- Occupational Therapy
Quite recently, there are a couple of breakthroughs for the treatment of Huntington's.
- Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients. [2]
- Using adult neurotrophic factor-secreting stem cells. [3]
<a href="http://www.disabled-world.com/health/neurology/breakthrough-cure.php">Huntington's Disease Breakthrough May Provide Cure</a>
