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Latest revision as of 16:10, 8 September 2023

News - Complete human day 14 post-implantation embryo models from naïve Embryonic Stem Cells

Carnegie Stage 6 Embryo

This recent Nature paper^[1] describes the use of naïve human Embryonic Stem Cells to recapitulate the early stages of human development.

"The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation....only genetically unmodified human naïve human ES cells...recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos including epiblast, hypoblast, extra-embryonic mesoderm, and trophoblast surrounding the latter layers...These human complete SEMs demonstrated developmental growth dynamics that resemble key hallmarks of post-implantation stage embryogenesis up to 13-14 days post-fertilization (dpf) (Carnegie stage 6a)."

Links: stem cells | Carnegie stage 6

↑ Oldak B, Wildschutz E, Bondarenko V, Comar MY, Zhao C, Aguilera-Castrejon A, Tarazi S, Viukov S, Pham TXA, Ashouokhi S, Lokshtanov D, Roncato F, Ariel E, Rose M, Livnat N, Shani T, Joubran C, Cohen R, Addadi Y, Chemla M, Kedmi M, Keren-Shaul H, Pasque V, Petropoulos S, Lanner F, Novershtern N & Hanna JH. (2023). Complete human day 14 post-implantation embryo models from naïve ES cells. Nature , , . PMID: 37673118 DOI.

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[PMID37673118-1] Oldak B, Wildschutz E, Bondarenko V, Comar MY, Zhao C, Aguilera-Castrejon A, Tarazi S, Viukov S, Pham TXA, Ashouokhi S, Lokshtanov D, Roncato F, Ariel E, Rose M, Livnat N, Shani T, Joubran C, Cohen R, Addadi Y, Chemla M, Kedmi M, Keren-Shaul H, Pasque V, Petropoulos S, Lanner F, Novershtern N & Hanna JH. (2023). Complete human day 14 post-implantation embryo models from naïve ES cells. Nature , , . PMID: 37673118 DOI.

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-| colspan=2|<span style="font-size:150%">'''Americas region is declared the world’s first to eliminate rubella'''</span>
+| <span style="font-size:150%">'''News - Complete human day 14 post-implantation embryo models from naïve Embryonic Stem Cells'''</span>
 |-bgcolor="F5FAFF"
-| valign=top|[[File:File:Rubella virus 03.jpg|alt=Rubella Virions|link=Abnormal Development - Rubella Virus|250px|left]]
+| valign=top|[[File:Stage6 bf03.jpg|thumb|150px|alt=Carnegie Stage 6 Embryo|Carnegie Stage 6 Embryo]]
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-"The Americas region has become the first in the world to be declared free of endemic transmission of rubella, a contagious viral disease that can cause multiple birth defects as well as fetal death when contracted by women during pregnancy."
-This achievement culminates a 15-year effort that involved widespread administration of the vaccine against measles, mumps and rubella (MMR) throughout the Western Hemisphere. The announcement comes as 45 countries and territories of the Americas are participating in the 13th annual Vaccination Week in the Americas (April 25 to May 2).
+This recent Nature paper{{#pmid:37673118|PMID37673118}} describes the use of naïve human Embryonic Stem Cells to recapitulate the early stages of human development.
-:(More? [[Abnormal Development - Rubella Virus|Rubella Virus]] | [http://www.paho.org/hq/index.php?option=com_content&view=article&id=10798%3Aamericas-free-of-rubella&Itemid=1926&lang=en WOO/PAHO Announcement])
+"The ability to study human post-implantation development remains limited due to ethical and technical challenges associated with intrauterine development after implantation....only genetically unmodified human naïve human ES cells...recapitulate the organization of nearly all known lineages and compartments of post-implantation human embryos including epiblast, hypoblast, extra-embryonic mesoderm, and trophoblast surrounding the latter layers...These human complete SEMs demonstrated developmental growth dynamics that resemble key hallmarks of post-implantation stage embryogenesis up to 13-14 days post-fertilization (dpf) (Carnegie stage 6a)."
-[[Template_talk:Main_Page_News|Older News Articles]] [[Template_talk:Main_Page_News#February|Three-person embryos]] | 2014 Nobel Prize in Medicine -  [http://www.nobelprize.org/nobel_prizes/medicine/laureates/2014/press.html Neural Development] | [[Neural_-_Hippocampus_Development|Hippocampus Development]] | WHO - Trends in Maternal Mortality 1990 to 2013 - [[Statistics - Maternal Mortality]] | [http://www.who.int/reproductivehealth/publications/monitoring/maternal-mortality-2013/en WHO Report Page] | WHO polio - [[Abnormal Development - Polio Virus|Polio Virus]] | Trisomy 21 - [[Template_talk:Main_Page_News#March|Genome-wide Effects]]
+:'''Links:''' {{stem cells}} | Carnegie stage {{CS6}}
-|}<noinclude>[[Category:Template]][[Category:2015]]</noinclude>
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+{| class="wikitable mw-collapsible mw-collapsed"
+! Older News Articles &nbsp;
+|-
+| [[Template_talk:Main_Page_News|'''Older News Articles''']] - [[Template_talk:Main_Page_News#January|Climate Change Abnormal Development]] | [[Template_talk:Main_Page_News#December|Air Pollution]] | [[Template_talk:Main_Page_News#February|Rare Sesquizygotic Twinning]] | [[Template_talk:Main_Page_News#June|Australia's mothers and babies 2017]] | [[Template_talk:Main_Page_News#October|Spinal Muscular Atrophy Screening]] | [[Template_talk:Main_Page_News#February|Australian 2018 Pregnancy Care Guidelines]] | [[Template_talk:Main_Page_News#July|CRISPR]] | [[Template_talk:Main_Page_News#June|Ronan O’Rahilly]]
+|}
+|}