Talk:Neural System - Abnormalities: Difference between revisions
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===Scanning electron microscopy of fetal murine myelomeningocele reveals growth and development of the spinal cord in early gestation and neural tissue destruction around birth=== | |||
J Pediatr Surg. 2007 Sep;42(9):1561-5. | |||
Stiefel D, Meuli M. | |||
Neural Development Unit, Institute of Child Health, University College London, London, WC1N 1EH United Kingdom. | |||
Abstract | |||
BACKGROUND: Previous studies demonstrated that the spinal cord within a fetal myelomeningocele (MMC) lesion suffers progressive destruction during gestation. This study aims at elucidating this pathophysiologic feature on a cellular and ultrastructural level in a model of genetically determined MMC. | |||
METHODS: Curly tail/loop tail mouse fetuses at various gestational stages and neonates were analyzed electron-microscopically to document time-point and nature of neural tissue development and pathologic alterations within the MMC. | |||
RESULTS: At embryonic day (E) 8.5 and E9.5, round cells displaying multiple microvilli covered the entire region of interest, and some specimens showed initial stages of neurulation. At E10.5, neurulation was terminated in normal animals, whereas the neural placode remained unfolded in MMC fetuses and became distinguishable from adjacent epidermal layers. At E15.5, an apparently normal differentiation was found. Until this time-point, there was no tissue damage or inflammation. Thereafter, increasingly severe tissue alterations were identified with ongoing gestation leading to almost complete loss of neural tissue at birth. | |||
CONCLUSION: We show here in fetal mice with MMC that, apart from absent neurulation, growth and development of the otherwise perfectly intact exposed spinal cord appear normal in early gestation, whereas later, the unprotected neural tissue is progressively destroyed. | |||
PMID: 17848249 | |||
==Neonatal Brain US by Erik Beek and Floris Groenendaal== | ==Neonatal Brain US by Erik Beek and Floris Groenendaal== | ||
ultrasound scans of head region http://www.radiologyassistant.nl/en/440c93be7456f | ultrasound scans of head region http://www.radiologyassistant.nl/en/440c93be7456f | ||
Revision as of 14:22, 15 October 2010
Scanning electron microscopy of fetal murine myelomeningocele reveals growth and development of the spinal cord in early gestation and neural tissue destruction around birth
J Pediatr Surg. 2007 Sep;42(9):1561-5.
Stiefel D, Meuli M.
Neural Development Unit, Institute of Child Health, University College London, London, WC1N 1EH United Kingdom. Abstract BACKGROUND: Previous studies demonstrated that the spinal cord within a fetal myelomeningocele (MMC) lesion suffers progressive destruction during gestation. This study aims at elucidating this pathophysiologic feature on a cellular and ultrastructural level in a model of genetically determined MMC.
METHODS: Curly tail/loop tail mouse fetuses at various gestational stages and neonates were analyzed electron-microscopically to document time-point and nature of neural tissue development and pathologic alterations within the MMC.
RESULTS: At embryonic day (E) 8.5 and E9.5, round cells displaying multiple microvilli covered the entire region of interest, and some specimens showed initial stages of neurulation. At E10.5, neurulation was terminated in normal animals, whereas the neural placode remained unfolded in MMC fetuses and became distinguishable from adjacent epidermal layers. At E15.5, an apparently normal differentiation was found. Until this time-point, there was no tissue damage or inflammation. Thereafter, increasingly severe tissue alterations were identified with ongoing gestation leading to almost complete loss of neural tissue at birth.
CONCLUSION: We show here in fetal mice with MMC that, apart from absent neurulation, growth and development of the otherwise perfectly intact exposed spinal cord appear normal in early gestation, whereas later, the unprotected neural tissue is progressively destroyed.
PMID: 17848249
Neonatal Brain US by Erik Beek and Floris Groenendaal
ultrasound scans of head region http://www.radiologyassistant.nl/en/440c93be7456f
Preconceptional Folate Supplementation and the Risk of Spontaneous Preterm Birth: A Cohort Study
http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000061
- "Preconceptional folate supplementation is associated with a 50%–70% reduction in the incidence of early spontaneous preterm birth. The risk of early spontaneous preterm birth is inversely proportional to the duration of preconceptional folate supplementation. Preconceptional folate supplementation was specifically related to early spontaneous preterm birth and not associated with other complications of pregnancy."
http://en.wikipedia.org/wiki/File:Encephalocele_of_a_newborn.JPG
<pubmed>19788802</pubmed>
