File:Human cochlea fetal development cartoon.jpg: Difference between revisions
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'''Gestational Week''' {{GA}} | '''Gestational Week''' {{GA}} | ||
* '''Week 10''' (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium. | * '''Week 10''' (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium. | ||
* '''Week 11''' (W11) - Penetration starts prior to hair cell differentiation. | * '''Week 11''' (W11) - Penetration starts prior to hair cell differentiation. | ||
* '''Week 12''' (W12) - The first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs. | * '''Week 12''' (W12) - The first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs. | ||
* '''Week 14''' (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2. | * '''Week 14''' (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2. | ||
* '''Week 20''' (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites. | * '''Week 20''' (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites. | ||
| valign=top|'''Abbreviations''' | | valign=top|'''Abbreviations''' | ||
* SGN - spiral ganglion neuron | * SGN - spiral ganglion neuron | ||
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:'''Links | :[[Hearing_-_Inner_Ear_Development|'''Cochlea Links''']]: [[:File:Human fetal cochlea 01.jpg|Image week 8]] | [[:File:Human fetal cochlea 02.jpg|Image week 10]] | [[:File:Human cochlea fetal development cartoon.jpg|Cochlea molecular cartoon]] | [[Hearing_-_Inner_Ear_Development|Inner Ear Development]] | ||
===Reference=== | ===Reference=== | ||
{{#pmid:24131517}} | |||
====Copyright==== | ====Copyright==== | ||
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Figure 9. 1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20 doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling. | Figure 9. 1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20 doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling. | ||
{{Footer}} | |||
[[Category:Human]] [[Category:Fetal]] [[Category:Hearing]] [[Category:Inner Ear]][[Category:Week 8]][[Category:Week 9]][[Category:10]][[Category:Week 12]][[Category:Week 18]] | [[Category:Human]] [[Category:Fetal]] [[Category:Hearing]] [[Category:Inner Ear]][[Category:Week 8]][[Category:Week 9]][[Category:Week 10]][[Category:Week 12]][[Category:Week 18]] |
Latest revision as of 21:07, 12 May 2019
Human Cochlea Fetal Development Cartoon
Schematic diagram of neurosensory development in the basal turn of the human fetal cochlea by Gestational Week GA
Gestational Week GA
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Abbreviations
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Reference
Locher H, Frijns JH, van Iperen L, de Groot JC, Huisman MA & Chuva de Sousa Lopes SM. (2013). Neurosensory development and cell fate determination in the human cochlea. Neural Dev , 8, 20. PMID: 24131517 DOI.
Copyright
© 2013 Locher et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Figure 9. 1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20 doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling.
Cite this page: Hill, M.A. (2024, June 16) Embryology Human cochlea fetal development cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Human_cochlea_fetal_development_cartoon.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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