File:Human cochlea fetal development cartoon.jpg: Difference between revisions

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Human Cochlea Fetal Development Cartoon

Schematic diagram of neurosensory development in the basal turn of the human fetal cochlea by Gestational Week GA

Gestational Week GA

Week 10 (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium.

Week 11 (W11) - Penetration starts prior to hair cell differentiation.

Week 12 (W12) - The first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs.

Week 14 (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2.

Week 20 (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites.

Abbreviations

SGN - spiral ganglion neuron
IHC - inner hair cell
O1 - first row of outer hair cells
O2 - second row of outer hair cells
O3 - third row of outer hair cells
OHC - outer hair cell.

Cochlea Links: Image week 8 | Image week 10 | Cochlea molecular cartoon | Inner Ear Development

Reference

Locher H, Frijns JH, van Iperen L, de Groot JC, Huisman MA & Chuva de Sousa Lopes SM. (2013). Neurosensory development and cell fate determination in the human cochlea. Neural Dev , 8, 20. PMID: 24131517 DOI.

Copyright

© 2013 Locher et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Figure 9. 1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20 doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling.

Cite this page: Hill, M.A. (2024, June 26) Embryology Human cochlea fetal development cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Human_cochlea_fetal_development_cartoon.jpg

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current	11:41, 29 June 2014		592 × 1,200 (96 KB)	Z8600021 (talk \| contribs)	Human cochlea fetal development cartoon © 2013 Locher et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which per...

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Hearing - Inner Ear Development

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@@ Line 1: / Line 1: @@
-Human cochlea fetal development cartoon
+==Human Cochlea Fetal Development Cartoon==
+Schematic diagram of neurosensory development in the basal turn of the human fetal cochlea by Gestational Week {{GA}}
+{|
+| width=600px|
+'''Gestational Week''' {{GA}}
+* '''Week 10''' (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium.
+* '''Week 11''' (W11) - Penetration starts prior to hair cell differentiation.
+* '''Week 12''' (W12) - The first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs.
+* '''Week 14''' (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2.
+* '''Week 20''' (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites.
+| valign=top|'''Abbreviations'''
+* SGN - spiral ganglion neuron
+* IHC -  inner hair cell
+* O1 -  first row of outer hair cells
+* O2 -  second row of outer hair cells
+* O3 -  third row of outer hair cells
+* OHC -  outer hair cell.
+|}
+:[[Hearing_-_Inner_Ear_Development|'''Cochlea Links''']]: [[:File:Human fetal cochlea 01.jpg|Image week 8]] | [[:File:Human fetal cochlea 02.jpg|Image week 10]] | [[:File:Human cochlea fetal development cartoon.jpg|Cochlea molecular cartoon]] | [[Hearing_-_Inner_Ear_Development|Inner Ear Development]]
+===Reference===
+{{#pmid:24131517}}
+====Copyright====
 © 2013 Locher et al.; licensee BioMed Central Ltd.
 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
--8104-8-20-9.jpg
+Figure 9.  1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20   doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling.
+{{Footer}}
+[[Category:Human]] [[Category:Fetal]] [[Category:Hearing]] [[Category:Inner Ear]][[Category:Week 8]][[Category:Week 9]][[Category:Week 10]][[Category:Week 12]][[Category:Week 18]]