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Human cochlea fetal development cartoon
==Human Cochlea Fetal Development Cartoon==
 
Schematic diagram of neurosensory development in the basal turn of the human fetal cochlea by Gestational Week {{GA}}
{|
| width=600px|
'''Gestational Week''' {{GA}}
 
* '''Week 10''' (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium.
 
* '''Week 11''' (W11) - Penetration starts prior to hair cell differentiation.
 
* '''Week 12''' (W12) - The first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs.
 
* '''Week 14''' (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2.
 
* '''Week 20''' (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites.
 
| valign=top|'''Abbreviations'''
* SGN - spiral ganglion neuron
* IHC -  inner hair cell
* O1 -  first row of outer hair cells
* O2 -  second row of outer hair cells
* O3 -  third row of outer hair cells
* OHC -  outer hair cell.
|}
 
 
:[[Hearing_-_Inner_Ear_Development|'''Cochlea Links''']]: [[:File:Human fetal cochlea 01.jpg|Image week 8]] | [[:File:Human fetal cochlea 02.jpg|Image week 10]] | [[:File:Human cochlea fetal development cartoon.jpg|Cochlea molecular cartoon]] | [[Hearing_-_Inner_Ear_Development|Inner Ear Development]]
 
 
===Reference===
{{#pmid:24131517}}
 
====Copyright====


© 2013 Locher et al.; licensee BioMed Central Ltd.  
© 2013 Locher et al.; licensee BioMed Central Ltd.  
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


1749-8104-8-20-9.jpg
Figure 9.  1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20  doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling.
{{Footer}}
[[Category:Human]] [[Category:Fetal]] [[Category:Hearing]] [[Category:Inner Ear]][[Category:Week 8]][[Category:Week 9]][[Category:Week 10]][[Category:Week 12]][[Category:Week 18]]

Latest revision as of 21:07, 12 May 2019

Human Cochlea Fetal Development Cartoon

Schematic diagram of neurosensory development in the basal turn of the human fetal cochlea by Gestational Week GA

Gestational Week GA

  • Week 10 (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium.
  • Week 11 (W11) - Penetration starts prior to hair cell differentiation.
  • Week 12 (W12) - The first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs.
  • Week 14 (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2.
  • Week 20 (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites.
Abbreviations
  • SGN - spiral ganglion neuron
  • IHC - inner hair cell
  • O1 - first row of outer hair cells
  • O2 - second row of outer hair cells
  • O3 - third row of outer hair cells
  • OHC - outer hair cell.


Cochlea Links: Image week 8 | Image week 10 | Cochlea molecular cartoon | Inner Ear Development


Reference

Locher H, Frijns JH, van Iperen L, de Groot JC, Huisman MA & Chuva de Sousa Lopes SM. (2013). Neurosensory development and cell fate determination in the human cochlea. Neural Dev , 8, 20. PMID: 24131517 DOI.

Copyright

© 2013 Locher et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Figure 9. 1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20 doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling.


Cite this page: Hill, M.A. (2024, June 16) Embryology Human cochlea fetal development cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Human_cochlea_fetal_development_cartoon.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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