Template:Second-generation BTKi table: Difference between revisions
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|+ ''' | |+ '''Second-generation Bruton’s Tyrosine Kinase Inhibitors (BTKi) for CCL Treatment''' | ||
|- | |-bgcolor="CEDFF2" | ||
! width= | ! width=110px|BTK inhibitor | ||
! width= | ! width=150px|BTK binding mechanism | ||
! width= | ! width=80px|Selectivity for BTK | ||
! width= | ! width=320px|Relevant non-BTK targets | ||
! width= | ! width=90px|Clinical Phase | ||
|- | |- | ||
| Acalabrutinib | | Acalabrutinib | ||
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| N/A | | N/A | ||
| II/III | | II/III | ||
|- | |-bgcolor="F5FAFF" | ||
| Zanubrutinib | | Zanubrutinib | ||
| Covalent, irreversible | | Covalent, irreversible | ||
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| N/A | | N/A | ||
| I/II | | I/II | ||
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| Vecabrutinib | | Vecabrutinib | ||
| Non-covalent, reversible | | Non-covalent, reversible | ||
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| N/A | | N/A | ||
| I | | I | ||
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| ARQ-531 | | ARQ-531 | ||
| Non-covalent, reversible | | Non-covalent, reversible | ||
| Low | | Low | ||
| Lck/Yes novel tyrosine kinase (LYN), mitogen-activated protein kinase kinase 1 (MEK1) | | Lck/Yes novel tyrosine kinase (LYN),<br>mitogen-activated protein kinase kinase 1 (MEK1) | ||
| I | | I | ||
|- | |- | ||
| colspan=5|Table data {{#pmid:31028669|PMID31028669}} | | colspan=5|Table data {{#pmid:31028669|PMID31028669}} | ||
|} | |} | ||
Latest revision as of 14:11, 30 April 2019
| BTK inhibitor | BTK binding mechanism | Selectivity for BTK | Relevant non-BTK targets | Clinical Phase |
|---|---|---|---|---|
| Acalabrutinib | Covalent, irreversible | High | N/A | II/III |
| Zanubrutinib | Covalent, irreversible | Moderate | N/A | II/III |
| Tirabrutinib | Covalent, irreversible | High | N/A | I/II |
| Vecabrutinib | Non-covalent, reversible | Moderate | interleukin-2-inducible (ITK) | I/II |
| LOXO-305 | Non-covalent, reversible | High | N/A | I |
| ARQ-531 | Non-covalent, reversible | Low | Lck/Yes novel tyrosine kinase (LYN), mitogen-activated protein kinase kinase 1 (MEK1) |
I |
| Table data [1] | ||||
