Template:Second-generation BTKi table: Difference between revisions
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! width=120px|BTK inhibitor | ! width=120px|BTK inhibitor | ||
! width=150px|BTK binding mechanism | ! width=150px|BTK binding mechanism | ||
! width= | ! width=80px|Selectivity for BTK | ||
! width= | ! width=220px|Relevant non-BTK targets | ||
! width=120px|Phase of clinical development | ! width=120px|Phase of clinical development | ||
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Revision as of 14:07, 30 April 2019
BTK inhibitor | BTK binding mechanism | Selectivity for BTK | Relevant non-BTK targets | Phase of clinical development |
---|---|---|---|---|
Acalabrutinib | Covalent, irreversible | High | N/A | II/III |
Zanubrutinib | Covalent, irreversible | Moderate | N/A | II/III |
Tirabrutinib | Covalent, irreversible | High | N/A | I/II |
Vecabrutinib | Non-covalent, reversible | Moderate | interleukin-2-inducible (ITK) | I/II |
LOXO-305 | Non-covalent, reversible | High | N/A | I |
ARQ-531 | Non-covalent, reversible | Low | Lck/Yes novel tyrosine kinase (LYN), mitogen-activated protein kinase kinase 1 (MEK1) |
I |
Table data [1] |