Template:Second-generation BTKi table: Difference between revisions

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| Non-covalent, reversible
| Non-covalent, reversible
| Low   
| Low   
| Lck/Yes novel tyrosine kinase (LYN), mitogen-activated protein kinase kinase 1 (MEK1)
| Lck/Yes novel tyrosine kinase (LYN),<br>mitogen-activated protein kinase kinase 1 (MEK1)
| I
| I
|-
|-
| colspan=5|Table data {{#pmid:31028669|PMID31028669}}
| colspan=5|Table data {{#pmid:31028669|PMID31028669}}
|}
|}

Revision as of 14:07, 30 April 2019

Novel Bruton’s Tyrosine Kinase (BTK) Inhibitors for CCL Treatment
BTK inhibitor BTK binding mechanism Selectivity for BTK Relevant non-BTK targets Phase of clinical development
Acalabrutinib Covalent, irreversible High N/A II/III
Zanubrutinib Covalent, irreversible Moderate N/A II/III
Tirabrutinib Covalent, irreversible High N/A I/II
Vecabrutinib Non-covalent, reversible Moderate interleukin-2-inducible (ITK) I/II
LOXO-305 Non-covalent, reversible High N/A I
ARQ-531 Non-covalent, reversible Low Lck/Yes novel tyrosine kinase (LYN),
mitogen-activated protein kinase kinase 1 (MEK1)
I
Table data [1]
  1. Bond DA & Woyach JA. (2019). Targeting BTK in CLL: Beyond Ibrutinib. Curr Hematol Malig Rep , , . PMID: 31028669 DOI.