Template:Second-generation BTKi table: Difference between revisions

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! width=120px|BTK inhibitor
! width=120px|BTK inhibitor
! width=120px|BTK binding mechanism
! width=120px|BTK binding mechanism
! Selectivity for BTK
! width=120px|Selectivity for BTK
! width=200px|Relevant non-BTK targets
! width=200px|Relevant non-BTK targets
! width=120px|Phase of clinical development
! width=120px|Phase of clinical development

Revision as of 14:03, 30 April 2019

Novel BTK Inhibitors for CCL Treatment
BTK inhibitor BTK binding mechanism Selectivity for BTK Relevant non-BTK targets Phase of clinical development
Acalabrutinib Covalent, irreversible High N/A II/III
Zanubrutinib Covalent, irreversible Moderate N/A II/III
Tirabrutinib Covalent, irreversible High N/A I/II
Vecabrutinib Non-covalent, reversible Moderate interleukin-2-inducible (ITK) I/II
LOXO-305 Non-covalent, reversible High N/A I
ARQ-531 Non-covalent, reversible Low Lck/Yes novel tyrosine kinase (LYN), mitogen-activated protein kinase kinase 1 (MEK1) I
Table data [1]
  1. Bond DA & Woyach JA. (2019). Targeting BTK in CLL: Beyond Ibrutinib. Curr Hematol Malig Rep , , . PMID: 31028669 DOI.