Talk:2018 Group Project 5: Difference between revisions
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[[User:Z5229431|Z5229431]] ([[User talk:Z5229431|talk]]) 12:16, 24 August 2018 (AEST) | [[User:Z5229431|Z5229431]] ([[User talk:Z5229431|talk]]) 12:16, 24 August 2018 (AEST) | ||
"Hedgehog (Hh) signal transduction is directly required in zebrafish DRG precursors for proper development of DRG neurons. Zebrafish mutations in the Hh signaling pathway result in the absence of DRG neurons and the loss of expression of neurogenin1 (ngn1), a gene required for determination of DRG precursors. Cell transplantation experiments demonstrate that Hh acts directly on DRG neuron precursors. Blocking Hh pathway activation at later stages of embryogenesis with the steroidal alkaloid, cyclopamine, further reveals that the requirement for a Hh signal response in DRG precursors correlates with the onset of ngn1 expression. These results suggest that Hh signaling may normally promote DRG development by regulating expression of ngn1 in DRG precursors." | |||
Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons. Josette M. Ungos, Rolf O. Karlstrom, David W. Raible. Development 2003 130: 5351-5362; doi: 10.1242/dev.00722 | |||
[[User:Z5229431|Z5229431]] ([[User talk:Z5229431|talk]]) 00:25, 28 August 2018 (AEST) | |||
==Current research (Labs)== | ==Current research (Labs)== |
Revision as of 00:25, 28 August 2018
Projects 2018: 1 Adrenal Medulla | 3 Melanocytes | 4 Cardiac | 5 Dorsal Root Ganglion |
Project Pages are currently being updated (notice removed when completed)
About this Discussion Page
The project discussion page is where your group members can post discussion on the project topic. This will be demonstrated in the practical tutorial in week 3.
Please follow these 3 simple rules:
- Never identify yourself or any other students by name, use only your student number.
- Only edit your own student page or your own group project page.
- Only add content that is both correctly cited and you have permission to reuse.
Group Assessment Criteria |
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Science Student Projects
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More Information on Assessment Criteria | Science Student Projects |
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Z5229399 (talk) 11:33, 14 August 2018 (AEST) Z5229597 (talk) 11:34, 14 August 2018 (AEST) Z5229431 (talk) 11:35, 14 August 2018 (AEST) Z5229549 (talk) 11:36, 14 August 2018 (AEST) Z5229438 (talk) 11:36, 21 August 2018 (AEST)
Introduction
- A good article for the overview of trunk neural crest cells
Vega-Lopez GA, Cerrizuela S & Aybar MJ. (2017). Trunk neural crest cells: formation, migration and beyond. Int. J. Dev. Biol. , 61, 5-15. PMID: 28287247 DOI.
Z5229431 (talk) 12:25, 24 August 2018 (AEST)
History
Embryonic Origins
Developmental Process
Adult Function
- Differentiation process
- When they start to function
Tissue / Organ structure
Molecular Mechanisms / Factors / Genes
"Blocking of CXCR4 by morpholino or shRNA in premigratory chick trunk neural crest cells leads to significantly fewer cells that reach the dorsal aorta and instead populate the dorsal root ganglia"
Kasemeier-Kulesa JC, McLennan R, Romine MH, Kulesa PM & Lefcort F. (2010). CXCR4 controls ventral migration of sympathetic precursor cells. J. Neurosci. , 30, 13078-88. PMID: 20881125 DOI.
Z5229431 (talk) 12:18, 24 August 2018 (AEST)
Abnormalities / Abnormal development
- Environmental factors
- Genetic mutations
- Images of how they look like
Animal Models
"In zebrafish, trunk NCCs start migrating along a medial pathway in-between the somites and the NT. These NCCs align to and are affected by slow muscle cells in the middle part of the somite"
Honjo Y & Eisen JS. (2005). Slow muscle regulates the pattern of trunk neural crest migration in zebrafish. Development , 132, 4461-70. PMID: 16162652 DOI.
Z5229431 (talk) 12:16, 24 August 2018 (AEST)
"Hedgehog (Hh) signal transduction is directly required in zebrafish DRG precursors for proper development of DRG neurons. Zebrafish mutations in the Hh signaling pathway result in the absence of DRG neurons and the loss of expression of neurogenin1 (ngn1), a gene required for determination of DRG precursors. Cell transplantation experiments demonstrate that Hh acts directly on DRG neuron precursors. Blocking Hh pathway activation at later stages of embryogenesis with the steroidal alkaloid, cyclopamine, further reveals that the requirement for a Hh signal response in DRG precursors correlates with the onset of ngn1 expression. These results suggest that Hh signaling may normally promote DRG development by regulating expression of ngn1 in DRG precursors."
Hedgehog signaling is directly required for the development of zebrafish dorsal root ganglia neurons. Josette M. Ungos, Rolf O. Karlstrom, David W. Raible. Development 2003 130: 5351-5362; doi: 10.1242/dev.00722
Z5229431 (talk) 00:25, 28 August 2018 (AEST)
Current research (Labs)
--Z5229438 (talk) 19:27, 27 August 2018 (AEST)
Glossary
- Brief, clear and concise