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==Mouse Embryo Computed Tomography==
==Mouse Embryo Computed Tomography==


Isosurface of E11.5 embryos scanned at 8-μm resolution.
Isosurface of of the CT-scanned embryo E11.5 scanned at 8-μm resolution.


Comparison of Virtual and Paraffin Histology of an E11.5 Embryo Scanned at 8 μm
Original File Name:journal.pgen.0020061.g001.tif (only A of figure is shown here)
 
:'''(A)''' Isosurface renderings of the CT-scanned embryo.
 
:'''(B)''' Maximum intensity projection of the same embryo, with overlying places of section.
 
:'''(C–E)''' Sagittal, coronal, and axial sections of an E11.5 littermate.
 
:'''(F–H)''' Sagittal, coronal, and axial computed tomography sections of the embryo in panels (A) and (B), corresponding to the planes of section in panels (C–E). At low-power magnification, virtual and true paraffin histology demonstrate a similar level of detail. Scale bar indicates 400 μm.
 
 
a, cardiac atrium; cv, cardinal vein; drg, dorsal root ganglia; fv, forebrain vesicle; liv, liver; nt, neural tube; v, cardiac ventricle; v4, fourth ventricle.
doi:10.1371/journal.pgen.0020061.g001
 
Original File Name:journal.pgen.0020061.g001.tif


<pubmed>16683035</pubmed>| [http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020061 PLoS Genetics]
<pubmed>16683035</pubmed>| [http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020061 PLoS Genetics]

Revision as of 10:01, 17 August 2010

Mouse Embryo Computed Tomography

Isosurface of of the CT-scanned embryo E11.5 scanned at 8-μm resolution.

Original File Name:journal.pgen.0020061.g001.tif (only A of figure is shown here)

<pubmed>16683035</pubmed>| PLoS Genetics

Citation: Johnson JT, Hansen MS, Wu I, Healy LJ, Johnson CR, et al. (2006) Virtual Histology of Transgenic Mouse Embryos for High-Throughput Phenotyping. PLoS Genet 2(4): e61. doi:10.1371/journal.pgen.0020061

Editor: Wayne Frankel, The Jackson Laboratory, United States of America

Received: January 23, 2006; Accepted: March 13, 2006; Published: April 28, 2006

Copyright: © 2006 Johnson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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