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(Merkel cells and touch domes: more than mechanosensory functions? Exp Dermatol. 2014 Oct;23(10):692-5. doi: 10.1111/exd.12456. Epub 2014 Jul 16. ==Integumentary touch dome functions== Xiao Y1, Williams JS, Brownell I. Abstract The touch dome (TD) i...)
 
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Merkel cells and touch domes: more than mechanosensory functions?
==Integumentary touch dome functions==
Exp Dermatol. 2014 Oct;23(10):692-5. doi: 10.1111/exd.12456. Epub 2014 Jul 16.
Schematic of the mouse touch dome. Markers reported to be expressed in Merkel cells and touch dome keratinocytes that suggest function.
 
 
:'''Links:''' [[Sensory - Touch Development]] | [[Immune System Development]] | [[Endocrine System Development]]


==Integumentary touch dome functions==
===Reference===


Xiao Y1, Williams JS, Brownell I.
<pubmed>24862916</pubmed>


Abstract
Exp Dermatol. 2014 Oct;23(10):692-5. doi: 10.1111/exd.12456. Epub 2014 Jul 16.


The touch dome (TD) is an innervated structure in the epidermis of mammalian skin. Composed of specialized keratinocytes and neuroendocrine Merkel cells, the TD has distinct molecular characteristics compared to the surrounding epidermal keratinocytes. Much of the research on Merkel cell function has focused on their role in mechanosensation, specifically light touch. Recently, more has been discovered about Merkel cell molecular characteristics and their cells of origin. Here we review Merkel cell and TD biology, and discuss potential functions beyond mechanosensation.
PMID 24862916 PMCID: PMC4180785 DOI: 10.1111/exd.12456
====Copyright====


Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
Figure 1. Schematic of the mouse touch dome. Markers reported to be expressed in Merkel cells and touch dome keratinocytes that suggest function.


KEYWORDS: Merkel cell; endocrine; immune; mechanosensation; touch dome


PMID 24862916 PMCID: PMC4180785 DOI: 10.1111/exd.12456
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[[Category:Integumentary]][[Category:Cartoon]]

Latest revision as of 10:21, 22 September 2016

Integumentary touch dome functions

Schematic of the mouse touch dome. Markers reported to be expressed in Merkel cells and touch dome keratinocytes that suggest function.


Links: Sensory - Touch Development | Immune System Development | Endocrine System Development

Reference

<pubmed>24862916</pubmed>

Exp Dermatol. 2014 Oct;23(10):692-5. doi: 10.1111/exd.12456. Epub 2014 Jul 16.

PMID 24862916 PMCID: PMC4180785 DOI: 10.1111/exd.12456

Copyright

Published 2014. This article is a U.S. Government work and is in the public domain in the USA. Figure 1. Schematic of the mouse touch dome. Markers reported to be expressed in Merkel cells and touch dome keratinocytes that suggest function.



Cite this page: Hill, M.A. (2024, May 23) Embryology Integumentary touch dome functions.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Integumentary_touch_dome_functions.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current10:02, 22 September 2016Thumbnail for version as of 10:02, 22 September 2016893 × 556 (97 KB)Z8600021 (talk | contribs)
10:02, 22 September 2016Thumbnail for version as of 10:02, 22 September 2016950 × 664 (115 KB)Z8600021 (talk | contribs)Merkel cells and touch domes: more than mechanosensory functions? Exp Dermatol. 2014 Oct;23(10):692-5. doi: 10.1111/exd.12456. Epub 2014 Jul 16. ==Integumentary touch dome functions== Xiao Y1, Williams JS, Brownell I. Abstract The touch dome (TD) i...

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