File:Sall4 limb skeletal elements model.jpg: Difference between revisions

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Model of Sall4 in the two-population model for the development of limb skeletal elements

Sal-like genes encode putative zinc finger transcription factors.

(C) Sall4 regulation of Gli3 differs in fore- and hindlimb progenitor cells.

(D) Model of Sall4 regulation of gene network in the putative anterior progenitors (red) and posterior progenitors (blue).

(E) Schematic drawing of skeletal elements derived from the putative anterior progenitors (red) and posterior progenitors (blue).

Links: Image - Mouse E10.5 hindlimb gene expression | Limb Development | Limb Abnormalities | Appendicular Skeleton | OMIM607343

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Proceedings National Academy of Sciences (PNAS) Liberalization of PNAS copyright policy: Noncommercial use freely allowed Note original Author should be contacted for permission to reuse for Educational purposes. See also PNAS Author Rights and Permission FAQs

Cozzarelli NR, Fulton KR, Sullenberger DM. Liberalization of PNAS copyright policy: noncommercial use freely allowed. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12399. PMID15314225 "Our guiding principle is that, while PNAS retains copyright, anyone can make noncommercial use of work in PNAS without asking our permission, provided that the original source is cited."

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Cite this page: Hill, M.A. (2024, June 27) Embryology Sall4 limb skeletal elements model.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Sall4_limb_skeletal_elements_model.jpg

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current	21:18, 24 January 2016		800 × 619 (88 KB)	Z8600021 (talk \| contribs)	==A model of the role of Sall4 in the two-population model for the development of limb skeletal elements== (C) Sall4 regulation of Gli3 differs in fore- and hindlimb progenitor cells. (D) Model of Sall4 regulation of gene network in the putative ant...

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 ==Model of Sall4 in the two-population model for the development of limb skeletal elements==
+Sal-like genes encode putative zinc finger transcription factors.
 (C) Sall4 regulation of Gli3 differs in fore- and hindlimb progenitor cells.
@@ Line 7: / Line 8: @@
 (E) Schematic drawing of skeletal elements derived from the putative anterior progenitors (red) and posterior progenitors (blue).
-===Reference===
+:'''Links:''' [[:File:Mouse E10.5 hindlimb gene expression.jpg|Image - Mouse E10.5 hindlimb gene expression]] | [[Musculoskeletal System - Limb Development|Limb Development]] | [[Musculoskeletal System - Limb Abnormalities|Limb Abnormalities]] | [[Musculoskeletal System - Appendicular Skeleton Development|Appendicular Skeleton]] | [http://www.omim.org/entry/607343 OMIM607343]
-{{PNAS}}
+===Reference===
+<pubmed>25848055</pubmed>
-Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5075-80. doi: 10.1073/pnas.1421949112. Epub 2015 Apr 6.
+{{PNAS}}
-Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements.
-Akiyama R1, Kawakami H1, Wong J2, Oishi I3, Nishinakamura R4, Kawakami Y5.
-Abstract
-Limb skeletal elements originate from the limb progenitor cells, which undergo expansion and patterning to develop each skeletal element. Posterior-distal skeletal elements, such as the ulna/fibula and posterior digits develop in a Sonic hedgehog (Shh)-dependent manner. However, it is poorly understood how anterior-proximal elements, such as the humerus/femur, the radius/tibia and the anterior digits, are developed. Here we show that the zinc finger factors Sall4 and Gli3 cooperate for proper development of the anterior-proximal skeletal elements and also function upstream of Shh-dependent posterior skeletal element development. Conditional inactivation of Sall4 in the mesoderm before limb outgrowth caused severe defects in the anterior-proximal skeletal elements in the hindlimb. We found that Gli3 expression is reduced in Sall4 mutant hindlimbs, but not in forelimbs. This reduction caused posteriorization of nascent hindlimb buds, which is correlated with a loss of anterior digits. In proximal development, Sall4 integrates Gli3 and the Plzf-Hox system, in addition to proliferative expansion of cells in the mesenchymal core of nascent hindlimb buds. Whereas forelimbs developed normally in Sall4 mutants, further genetic analysis identified that the Sall4-Gli3 system is a common regulator of the early limb progenitor cells in both forelimbs and hindlimbs. The Sall4-Gli3 system also functions upstream of the Shh-expressing ZPA and the Fgf8-expressing AER in fore- and hindlimbs. Therefore, our study identified a critical role of the Sall4-Gli3 system at the early steps of limb development for proper development of the appendicular skeletal elements.
-KEYWORDS:
-Gli3; Plzf-Hox; Sall4; appendicular skeletal elements; limb progenitors
-PMID 25848055
+{{Footer}}
+[[Category:Limb]][[Category:Cartoon]][[Category:Sonic Hedgehog]]
+[[Category:Molecular]]