2015 Group Project 1: Difference between revisions
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Here is a good source for overview and status of 3 Person IVF. http://www.geneticsandsociety.org/article.php?id=6527 | Here is a good source for overview and status of 3 Person IVF. http://www.geneticsandsociety.org/article.php?id=6527 | ||
=History= | |||
=Benefits= | |||
PMID: 25629662 '''Mitocondrial donation--how many women could benefit?'''<ref><pubmed> 25629662 </pubmed></ref> | |||
This is a statistical analysis of the prevalence of women of child bearing age that have pathogenic mutation to their mitochondria that could benefit from mitochondrial donation in the UK. And the affects of the mitochondrial mutation on fertility as compared to background natural birth rate. They found no difference in fertility rates and 4% of women at risk of passing on symptomatic mitochondrial disease. | |||
=Methods= | =Methods= | ||
=Ethics= | =Ethics= | ||
Revision as of 10:41, 28 August 2015
| 2015 Student Projects | ||||
|---|---|---|---|---|
| 2015 Projects: Three Person Embryos | Ovarian Hyper-stimulation Syndrome | Polycystic Ovarian Syndrome | Male Infertility | Oncofertility | Preimplantation Genetic Diagnosis | Students | ||||
| 2015 Group Project Topic - Assisted Reproductive Technology | ||||
| This page is an undergraduate science embryology student and may contain inaccuracies in either description or acknowledgements. | ||||
Possible topics
Your own selected topic (consult coordinator)
oocyte quality
spermatozoa quality
frozen oocytes
in vitro oocyte development
assisted hatching
cryopreserved ovarian tissue
3 person embryos
fertility drugs
Three Person Embryos
(intro) Here is a good source for overview and status of 3 Person IVF. http://www.geneticsandsociety.org/article.php?id=6527
History
Benefits
PMID: 25629662 Mitocondrial donation--how many women could benefit?[1] This is a statistical analysis of the prevalence of women of child bearing age that have pathogenic mutation to their mitochondria that could benefit from mitochondrial donation in the UK. And the affects of the mitochondrial mutation on fertility as compared to background natural birth rate. They found no difference in fertility rates and 4% of women at risk of passing on symptomatic mitochondrial disease.
Methods
Ethics
Legal Status
Further Reading
useful publications:
PMID: 23608245 The ethics of creating children with three genetic parents. [2]
PMID: 24382342 Three-Parent IVF: Gene Replacement for the Prevention of Inherited Mitochondrial Diseases.[3]
PMID: 20933103 Mitochondrial function in the human oocyte and embryo and their role in developmental competence.[4]
PMID: 26020522 Mitochondrial reshaping accompanies neural differentiation in the developing spinal cord.[5]
PMID: 25421171 The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility.[6]
PMID: 26239841 The ethical challenges of the clinical introduction of mitochondrial replacement techniques.[7]
PMID: 21059727 Ethics of mitochondrial gene replacement: from bench to bedside.[8]
PMID: 25888328 Mitochondrial replacement to prevent the transmission of mitochondrial DNA disease.[9]
PMID: 25859028 Medicine. Transatlantic lessons in regulation of mitochondrial replacement therapy.[10]
PMID: 25807984 Risks inherent to mitochondrial replacement.[11]
Glossary
References
- ↑ <pubmed> 25629662 </pubmed>
- ↑ <pubmed> 23608245</pubmed>
- ↑ <pubmed> 24382342</pubmed>
- ↑ <pubmed> 20933103 </pubmed>
- ↑ <pubmed> 26020522 </pubmed>
- ↑ <pubmed> 25421171</pubmed>
- ↑ <pubmed> 26239841</pubmed>
- ↑ <pubmed> 21059727</pubmed>
- ↑ <pubmed> 25888328</pubmed>
- ↑ <pubmed> 25859028</pubmed>
- ↑ <pubmed> 25807984</pubmed>
