File:Zebrafish ectodermal patterning model.jpg: Difference between revisions

A two-step model for zebrafish ectodermal patterning. Step 1 depicts the DV gradient present during gastrulation. High BMP activity is observed ventrally as generated by bmp2b/4/7a ligand expression and reinforced by Cvl2. BMP activity is inhibited dorsally by expression of the diffusible antagonists Chordin and Noggin. Prospective PPE and NC are formed at intermediate levels of BMP signalling. In step 2 the initial gradient has reshaped into distinct BMP activity domains during neurulation. The regulatory network is depicted. Components in black act positively, whereas those in red act negatively. NC, neural crest; PPE, preplacodal ectoderm.

Reference

PMID 24089471

http://dev.biologists.org/content/140/21/4435.full?sid=f4d5ee3c-1ddc-44e4-9174-82c75a2e9577

Copyright

© 2013. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.