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Natural and Induced Intraepithelial Lymphocyte Function

The beneficial roles of natural and induced intraepithelial lymphocytes (IELs) in preserving the epithelium and restoring tissue integrity after injury.

Natural IELs - (previously ‘type b’ IELs) acquire activated phenotype during development in the thymus in the presence of self antigens.
Induced IELs - (previously ‘type a’ IELs) progeny of conventional T cells activated post-thymically in response to peripheral antigens.

Reference

<pubmed>21681197</pubmed>| Nat Rev Immunol.

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Licensee: Mark A Hill License Date: Jan 25, 2015 License Number: 3556220285761 Publication: Nature Reviews Immunology Title: The light and dark sides of intestinal intraepithelial lymphocytes Type Of Use: post on a website Figure 1. Nihms307956-23.jpg

Cite this page: Hill, M.A. (2026, October 25) Embryology Intraepithelial lymphocyte differentiation 03.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Intraepithelial_lymphocyte_differentiation_03.jpg

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current	15:50, 26 Ocak 2015		600 × 484 (68 KB)	Z8600021 (talk \| contribs)	==Thymic and peripheral differentiation of natural and induced intraepithelial lymphocytes== * IELs - intraepithelial lymphocytes * MLNs - mesenteric lymph nodes * APC - antigen-presenting cell In the thymus, immature CD4+CD8αβ+CD8αα+ (triple pos...

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Immune System Development

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-==Thymic and peripheral differentiation of natural and induced intraepithelial lymphocytes==
+==Natural and Induced Intraepithelial Lymphocyte Function==
-* IELs - intraepithelial lymphocytes
+The beneficial roles of natural and induced intraepithelial lymphocytes (IELs) in preserving the epithelium and restoring tissue integrity after injury.
-* MLNs - mesenteric lymph nodes
-* APC - antigen-presenting cell
-In the thymus, immature CD4+CD8αβ+CD8αα+ (triple positive) thymocytes undergo agonist (‘alternative’) selection and differentiate into double-negative T cell receptor-αβ (TCRαβ)+ cells that are the precursors of natural TCRαβ+ intraepithelial lymphocytes (IELs). The TCRαβ+ natural IEL precursor cells partly acquire their antigen-experienced phenotype ‘naturally’ during selection with self antigens.
+* '''Natural IELs''' - (previously ‘type b’ IELs) acquire activated phenotype during development in the thymus in the presence of self antigens.
+* '''Induced IELs''' - (previously ‘type a’ IELs) progeny of conventional T cells activated post-thymically in response to peripheral antigens.
-Precursor cells for TCRαβ+ and TCRγδ+ natural IELs upregulate intestinal homing receptors during their maturation in the thymus, which allows these cells to directly seed the intestinal epithelium after they leave the thymus. CD4+CD8αβ+ (double positive) thymocytes undergo ‘conventional’ thymic selection and differentiate into naive CD4+ and CD8αβ+ TCRαβ+ T cells that migrate to the periphery.
-These naive T cells can differentiate into effector T cells in response to peripheral antigens and subsequently migrate to the gut and become incorporated into the induced IEL compartment.