2014 Group Project 5: Difference between revisions
No edit summary |
No edit summary |
||
| Line 89: | Line 89: | ||
===Hair=== | ===Hair=== | ||
*'''Congenital alopecia areata''' | *'''Congenital alopecia areata''' | ||
:Alopecia areata (AA) is an abnormality of the hair affecting anagen hair follicles, characterised by well-demarcated patches of hair loss. It is non-scarring and can occur on the scalp and/or the body. 90% of AA cases occur on the scalp. 5%-10% of patients with AA lose all hair on their scalp; this is called alopecia totalis. While others lose all of their body hair, this is called alopecia universalis. | :Alopecia areata (AA) is an abnormality of the hair affecting anagen hair follicles, characterised by well-demarcated patches of hair loss. It is non-scarring and can occur on the scalp and/or the body. 90% of AA cases occur on the scalp. 5%-10% of patients with AA lose all hair on their scalp; this is called alopecia totalis. While others lose all of their body hair, this is called alopecia universalis. Its pathogenesis is considered to be both genetic and autoimmune. There is an abnormality with the genes related to the immune system and to the hair follicles. And histopathology shows signs of lymphatic infiltration of the hair follicles and the loss of these scalp lymphocytes allow hair follicles to recover. | ||
:There is currently no cure for AA. There are several treatments to combat AA but none of these have led to remission of the disease, the most effective being corticosteroids and topical immunotherapy. Recently, a new method of treating alopecia areata is being studied. Transepidermal drug delivery (TED) is a new treatment that functions by creating micro-channels in the epidermis. By doing so, drug delivery to the skin is improved. This treatment was highly effective and had lower rates of side effects, e.g. pain, compared to previous treatments. | :There is currently no cure for AA. There are several treatments to combat AA but none of these have led to remission of the disease, the most effective being corticosteroids and topical immunotherapy. Recently, a new method of treating alopecia areata is being studied. Transepidermal drug delivery (TED) is a new treatment that functions by creating micro-channels in the epidermis. By doing so, drug delivery to the skin is improved. This treatment was highly effective and had lower rates of side effects, e.g. pain, compared to previous treatments. | ||
Revision as of 22:04, 1 October 2014
| 2014 Student Projects | ||||
|---|---|---|---|---|
| 2014 Student Projects: Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7 | Group 8 | ||||
| The Group assessment for 2014 will be an online project on Fetal Development of a specific System.
This page is an undergraduate science embryology student and may contain inaccuracies in either description or acknowledgements. | ||||
Integumentary
--Mark Hill (talk) 15:16, 26 August 2014 (EST) OK you have some headings, how about some content, references, sources for each section. See Lab 3 Assessment.
--Mark Hill (talk) 11:48, 6 September 2014 (EST) This is a start. Less textbook referencing please, more research/reviews from the published literature. Textbooks should not be used as primary sources, I am happy for them to be listed as related literature.
Introduction
Development Overview
Skin
| Week | Description | Phase Diagram |
|---|---|---|
| Week 4-5 | Example | Example |
| Week 5-6 | Example | Example |
| Week 8-10 | Example | Example |
| Week 12 | Example | Example |
| Week 40 (birth) | Example | Example |
| Adult | Example | Example |
Glands
Hair
Nail
Teeth
<pubmed>19701759</pubmed>
Current Research
- Fetal skin wound healing:[1]
- Biology and function of fetal and pediatric skin:[2]
- Selective D2-40 lymphatic endothelium immunoreactivity in developing human fetal skin appendages:[3]
Historic Findings
Skin
Glands
Sebacious glands
Sweat glands
Hair
Technology
The
<pubmed>5656140</pubmed>
The development of hair was noted to be a cycling phenomenon in 1959 from Chase and Eaton's experiments on the.
In 1953 Chase, Montagna and Malone concluded that with the development of the hair follicle the surrounding skin goes under. They determined the mechanism of hair follicle development.
Downwards growth of the follicle from the level of the dermis during the quiecent phase thought he adipose layer during gowth and differntiation.
They also established that upward movement of hair inovlves the addition of ne cells from the matrix of the follicle and an enlargement of each cell.
Furthermore their research also showed that the epidermal and dermal layers were dynamic and interacting with each other.
The most significant developments in the understanding of hair follicle development came from studies investigating the differentiation pattern of cells as the follicle develops.
<pubmed>4097391</pubmed>
Nail
Teeth
Abnormalities
Skin
- Cutis Aplasia
- Neuroblastoma
- Albinism
- Melanoma
Glands
- Hypohidrotic Ectodermal Dysplasia
<pubmed>25140498</pubmed>
Hair
- Congenital alopecia areata
- Alopecia areata (AA) is an abnormality of the hair affecting anagen hair follicles, characterised by well-demarcated patches of hair loss. It is non-scarring and can occur on the scalp and/or the body. 90% of AA cases occur on the scalp. 5%-10% of patients with AA lose all hair on their scalp; this is called alopecia totalis. While others lose all of their body hair, this is called alopecia universalis. Its pathogenesis is considered to be both genetic and autoimmune. There is an abnormality with the genes related to the immune system and to the hair follicles. And histopathology shows signs of lymphatic infiltration of the hair follicles and the loss of these scalp lymphocytes allow hair follicles to recover.
- There is currently no cure for AA. There are several treatments to combat AA but none of these have led to remission of the disease, the most effective being corticosteroids and topical immunotherapy. Recently, a new method of treating alopecia areata is being studied. Transepidermal drug delivery (TED) is a new treatment that functions by creating micro-channels in the epidermis. By doing so, drug delivery to the skin is improved. This treatment was highly effective and had lower rates of side effects, e.g. pain, compared to previous treatments.
<pubmed>15692503</pubmed> <pubmed>17269961</pubmed> <pubmed>16338213</pubmed> <pubmed>23947678</pubmed> <pubmed>25000998</pubmed> <pubmed>25260052</pubmed>
Nail
- Anonychia
- Ectopic Nail
Teeth
- Adontia
- Amelogenesis imperfecta
