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==Human cochlea fetal development cartoon==
==Human Cochlea Fetal Development Cartoon==


Schematic diagram of neurosensory development in the basal turn of the human feral cochlea by Gestational Week {{GA}}
Schematic diagram of neurosensory development in the basal turn of the human feral cochlea by Gestational Week {{GA}}
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Gestational Week {{GA}}
Gestational Week {{GA}}
* '''Week 10''' (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium.  
* '''Week 10''' (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium.  
* '''Week 11''' (W11) - Penetration starts prior to hair cell differentiation. At W12, the first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs.  
* '''Week 11''' (W11) - Penetration starts prior to hair cell differentiation.  
* '''Week 12''' (W12) - The first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs.  
* '''Week 14''' (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2.  
* '''Week 14''' (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2.  
* '''Week 20''' (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites.  
* '''Week 20''' (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites.  
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Figure 9.  1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20  doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling.
Figure 9.  1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20  doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling.


[[Category:Human]] [[Category:Fetal]] [[Category:Hearing]] [[Category:Inner Ear]][[Category:Week 8]][[Category:Week 9]][[Category:Week 12]][[Category:Week 18]]
[[Category:Human]] [[Category:Fetal]] [[Category:Hearing]] [[Category:Inner Ear]][[Category:Week 8]][[Category:Week 9]][[Category:10]][[Category:Week 12]][[Category:Week 18]]

Revision as of 11:54, 29 June 2014

Human Cochlea Fetal Development Cartoon

Schematic diagram of neurosensory development in the basal turn of the human feral cochlea by Gestational Week GA

Gestational Week GA

  • Week 10 (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium.
  • Week 11 (W11) - Penetration starts prior to hair cell differentiation.
  • Week 12 (W12) - The first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs.
  • Week 14 (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2.
  • Week 20 (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites.
 Abbreviations
  • SGN - spiral ganglion neuron
  • IHC - inner hair cell
  • O1 - first row of outer hair cells
  • O2 - second row of outer hair cells
  • O3 - third row of outer hair cells
  • OHC - outer hair cell.


Links: Inner Ear Development

Reference

<pubmed>24131517</pubmed>| Neural Dev.

Copyright

© 2013 Locher et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Figure 9. 1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20 doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling.

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