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==Human cochlea fetal development cartoon== | ==Human cochlea fetal development cartoon== | ||
Schematic diagram of neurosensory development in the basal turn of the human | Schematic diagram of neurosensory development in the basal turn of the human feral cochlea by Gestational Week {{GA}} | ||
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Gestational Week {{GA}} | |||
* '''Week 10''' (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium. | * '''Week 10''' (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium. | ||
* '''Week 11''' (W11) - Penetration starts prior to hair cell differentiation. At W12, the first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs. | * '''Week 11''' (W11) - Penetration starts prior to hair cell differentiation. At W12, the first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs. | ||
* '''Week 14''' (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2. | * '''Week 14''' (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2. | ||
* '''Week 20''' (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites. | * '''Week 20''' (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites. | ||
| Abbreviations | | valign=top|'''Abbreviations''' | ||
* SGN - spiral ganglion neuron | * SGN - spiral ganglion neuron | ||
* IHC - inner hair cell | * IHC - inner hair cell | ||
Revision as of 11:51, 29 June 2014
Human cochlea fetal development cartoon
Schematic diagram of neurosensory development in the basal turn of the human feral cochlea by Gestational Week GA
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Gestational Week GA
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Abbreviations
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- Links: Inner Ear Development
Reference
<pubmed>24131517</pubmed>| Neural Dev.
Copyright
© 2013 Locher et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Figure 9. 1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20 doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling.
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