File:Human cochlea fetal development cartoon.jpg: Difference between revisions

From Embryology
mNo edit summary
mNo edit summary
Line 1: Line 1:
==Human cochlea fetal development cartoon==
==Human cochlea fetal development cartoon==


Schematic diagram of neurosensory development in the basal turn of the human fetal cochlea.
Schematic diagram of neurosensory development in the basal turn of the human feral cochlea by Gestational Week {{GA}}
{|
{|
| width=400px|
| width=500px|
Gestational Week {{GA}}
* '''Week 10''' (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium.  
* '''Week 10''' (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium.  
* '''Week 11''' (W11) - Penetration starts prior to hair cell differentiation. At W12, the first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs.  
* '''Week 11''' (W11) - Penetration starts prior to hair cell differentiation. At W12, the first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs.  
* '''Week 14''' (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2.  
* '''Week 14''' (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2.  
* '''Week 20''' (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites.  
* '''Week 20''' (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites.  
| Abbreviations
| valign=top|'''Abbreviations'''
* SGN - spiral ganglion neuron
* SGN - spiral ganglion neuron
* IHC -  inner hair cell
* IHC -  inner hair cell

Revision as of 11:51, 29 June 2014

Human cochlea fetal development cartoon

Schematic diagram of neurosensory development in the basal turn of the human feral cochlea by Gestational Week GA

Gestational Week GA

  • Week 10 (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium.
  • Week 11 (W11) - Penetration starts prior to hair cell differentiation. At W12, the first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs.
  • Week 14 (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2.
  • Week 20 (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites.
Abbreviations
  • SGN - spiral ganglion neuron
  • IHC - inner hair cell
  • O1 - first row of outer hair cells
  • O2 - second row of outer hair cells
  • O3 - third row of outer hair cells
  • OHC - outer hair cell.


Links: Inner Ear Development

Reference

<pubmed>24131517</pubmed>| Neural Dev.

Copyright

© 2013 Locher et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Figure 9. 1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20 doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling.

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current11:41, 29 June 2014Thumbnail for version as of 11:41, 29 June 2014592 × 1,200 (96 KB)Z8600021 (talk | contribs)Human cochlea fetal development cartoon © 2013 Locher et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which per...

The following page uses this file:

Metadata