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Trisomy 21 Genomw-wide Effects

"A comparison of identical human twins, only one of whom has Down's syndrome, reveals a genome-wide flattening of gene-expression levels in the affected individual. These results indicate that the nuclear compartments of trisomic cells undergo modifications of the chromatin environment influencing the overall transcriptome, and that gene expression dysregulation domains (GEDDs) may therefore contribute to some trisomy 21 phenotypes."

(More? Trisomy 21 | Trisomy 18 | Prenatal Diagnosis)

Reference: Nature Published online 16 April 2014

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-: "A comparison of identical human twins, only one of whom has Down's syndrome, reveals a genome-wide flattening of gene-expression levels in the affected individual. These results indicate that the nuclear compartments of trisomic cells undergo modifications of the chromatin environment influencing the overall transcriptome, and that GEDDs may therefore contribute to some trisomy 21 phenotypes."
+: "A comparison of identical human twins, only one of whom has Down's syndrome, reveals a genome-wide flattening of gene-expression levels in the affected individual. These results indicate that the nuclear compartments of trisomic cells undergo modifications of the chromatin environment influencing the overall transcriptome, and that gene expression dysregulation domains (GEDDs)  may therefore contribute to some trisomy 21 phenotypes."