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Stimulus-triggered fate conversion of somatic cells into pluripotency

Stimulus-triggered acquisition of pluripotency 01.jpg

"Here we report a unique cellular reprogramming phenomenon, called stimulus-triggered acquisition of pluripotency (STAP), which requires neither nuclear transfer nor the introduction of transcription factors. In STAP, strong external stimuli such as a transient low-pH stressor reprogrammed mammalian somatic cells, resulting in the generation of pluripotent cells."

(More? Induced Stem Cells | Stem Cells)

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-| colspan=2|<span style="font-size:150%">'''2012 Nobel Prize for Stem Cells'''</span>
+| colspan=2|<span style="font-size:150%">'''Stimulus-triggered fate conversion of somatic cells into pluripotency'''</span>
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-| [[File:Mouse-_embryonic_stem_cell_signaling_regulation.jpg|200px|link=Stem_Cells_-_Induced]]
+| [[File:Stimulus-triggered acquisition of pluripotency 01.jpg]]
-| &nbsp;‎‎'''Stem Cell Signaling'''
+|-
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+:"Here we report a unique cellular reprogramming phenomenon, called stimulus-triggered acquisition of pluripotency (STAP), which requires neither nuclear transfer nor the introduction of transcription factors. In STAP, strong external stimuli such as a transient low-pH stressor reprogrammed mammalian somatic cells, resulting in the generation of pluripotent cells."
-[http://www.nobelprize.org/nobel_prizes/medicine/laureates/2012 Nobel Prize] | [[Stem Cells]]
+(More? [[Stem_Cells_-_Induced|Induced Stem Cells]] | [[Stem Cells]])
-The Nobel Prize in Physiology or Medicine 2012 was awarded jointly to Sir John B. Gurdon and Shinya Yamanaka "''for the discovery that mature cells can be reprogrammed to become pluripotent''"
-* '''Yamanaka Factors''' Are a set of 4 transcription factors when introduced into cells induces stem cell formation. PMID 16904174 | PMID 18035408 | PMID 20535199
-* '''John Gurdon''' used nuclear transplantation and cloning to show that the nucleus of a differentiated somatic cell retains the totipotency necessary to form a whole organism. [http://www.sciencedirect.com/science/article/pii/S0960982203006845 2003 Current Biology Interview] PMID 14521852 2009 Interview - [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615171 "The birth of cloning"] PMID 19132124
-(More? [[Stem_Cells_-_Induced#Yamanaka_Factors|Yamanaka Factors]] | [[Stem_Cells_-_Induced|Induced Stem Cells]] | [[Stem Cells]])
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