Embryology History - Shinya Yamanaka: Difference between revisions
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'''Search PubMed Now:''' ** [http://www.ncbi.nlm.nih.gov/pubmed?term=Yamanaka+S%5BAuthor%5D&cmd=DetailsSearch Yamanaka+S] | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=induced%20pluripotent%20stem%20cell induced pluripotent stem cell] | | '''Search PubMed Now:''' ** [http://www.ncbi.nlm.nih.gov/pubmed?term=Yamanaka+S%5BAuthor%5D&cmd=DetailsSearch Yamanaka+S] | [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=induced%20pluripotent%20stem%20cell induced pluripotent stem cell] | | ||
==External Links== | |||
{{External Links}} | |||
* [http://archive.sciencewatch.com/inter/aut/2009/09-jun/09junYama/ 2009 ScienceWatch interview] |
Revision as of 09:43, 9 October 2012
Introduction
Draft Page
- Links: Induced Stem Cells | Stem Cells
Some Recent Findings
The Nobel Prize in Physiology or Medicine 2012 was awarded jointly to Sir John B. Gurdon and Shinya Yamanaka
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Recent References | References
Yamanaka Factors
Yamanaka Factors[1][2] Are a set of 4 transcription factors when introduced into cells induces stem cell formation. These four transcription factors can be expressed from doxycycline (dox)-inducible lentiviral vectors.
OCT4
- Transcription factors containing the POU homeodomain
- Links: OMIM - OCT4
SOX2
- Sry-related HMG-Box gene 2
- Links: OMIM - SOX2
KLF4
- Kruppel-like factor 4, zinc finger protein, transcription factor which acts as both an activator and repressor.
- Links: OMIM - KLF4
cMyc
- The MYC protooncogene encodes a DNA-binding factor that can activate and repress transcription.
- Ectopic expression of c-Myc can also cause tumorigenicity in offspring.
- Links: OMIM - MYC
- More recently shown that Oct4 together with either Klf4 or c-Myc is sufficient to generate iPS cells from neural stem cells.[3]
- Tbx3 transcription factor significantly improves the quality of iPS cells.[4]
References
Reviews
<pubmed></pubmed> <pubmed></pubmed> <pubmed></pubmed>
Articles
<pubmed>20535199</pubmed> <pubmed>18035408</pubmed> <pubmed>16904174</pubmed>
Journal of Visualized Experiments - Generating iPS Cells from MEFS through Forced Expression of Sox-2, Oct-4, c-Myc, and Klf4
Search PubMed
Search PubMed Now: ** Yamanaka+S | induced pluripotent stem cell |
External Links
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