Talk:Advanced - Cardiac Conduction

From Embryology

--Mark Hill 08:55, 29 October 2009 (EST) Search development cardiac conduction | cardiac conduction |

  • Genetic and Physiologic Dissection of the Vertebrate Cardiac Conduction System Neil C Chi, Robin M Shaw, Benno Jungblut, Jan Huisken, Tania Ferrer, Rima Arnaout, Ian Scott, Dimitris Beis, Tong Xiao, Herwig Baier, Lily Y Jan, Martin Tristani-Firouzi, and Didier Y. R Stainier PLoS Biol. 2008 May; 6(5): e109. Published online 2008 May 13. doi: 10.1371/journal.pbio.0060109. PMCID: PMC2430899

  • cardiac voltage-gated sodium channels - conduction in the normal heart required for fast upstroke of the action potential
  • arrhythmogenesis
  • conduction disease
  • The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium C. A. Remme, A. O. Verkerk, W. M. H. Hoogaars, W. T. J. Aanhaanen, B. P. Scicluna, C. Annink, M. J. B. van den Hoff, A. A. M. Wilde, T. A. B. van Veen, M. W. Veldkamp, J. M. T. de Bakker, V. M. Christoffels, and C. R. Bezzina Basic Res Cardiol. 2009 September; 104(5): 511–522. Published online 2009 March 3. doi: 10.1007/s00395-009-0012-8. PMCID: PMC2722719
"Nav1.5 was observed to be heterogeneously expressed in the cardiac conduction system, with low abundance in the nodal tissues and high expression in the intraventricular conduction system. In addition, a transmural gradient across the ventricular wall exists, with low Nav1.5 labeling intensity and functional sodium channel availability in the subepicardium compared to subendocardium."
  • Lamin A/C truncation in dilated cardiomyopathy with conduction disease Heather M MacLeod, Mary R Culley, Jill M Huber, and Elizabeth M McNally BMC Med Genet. 2003; 4: 4. Published online 2003 July 10. doi: 10.1186/1471-2350-4-4. PMCID: PMC169171

--Phoebe Norville 14:35, 2 October 2009 (EST)

File:HeartILP draft conduction.jpg
Diagram of the adult cardiac conduction system