File:Spindle assembly motors 01.jpg
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Motor activities in spindle assembly
Microtubule (MT)-bound motors promote bipolar spindle formation, whereas chromosome-associated motors drive proper kinetochore orientation and chromosome movement to the equator.
| Box 1 | Box 2 | Box 3 | Box 4 | Box 5 |
|---|---|---|---|---|
| Motor-dependent mechanisms establish bipolarity as Eg5 (kinesin-5) motors slide antiparallel microtubules apart with their minus ends leading and their plus ends directed toward the spindle equator. | Minus end–directed motors such as dynein move microtubules poleward with their minus ends leading, thereby incorporating K-fibers into the spindle and focusing spindle poles. | Kinetochore-associated dynein transports chromosomes along astral microtubules toward the spindle poles from the periphery. | Plus end–directed chromokinesins (kinesin-4 and -10) eject chromosome arms outward. | CENP-E (kinesin-7) transports unattached kinetochores toward the equator along spindle microtubules. MTOC, microtubule organizing centre. |
Reference
<pubmed>26668328</pubmed>
http://jcb.rupress.org/content/211/6/1103.full Figure 3.
© 2015 Heald and Khodjakov.
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