File:Skeletal muscle basal lamina exp01.jpg

Frog Skeletal Muscle Basal Lamina Experiment

• Basal lamina directs acetylcholinesterase (AChE) accumulation at synaptic sites in regenerating muscle.
• skeletal muscle damaged such that basal lamina sheaths of the muscle fibers spared
• new myofibers develop within sheaths and neuromuscular junctions form at original synaptic sites
• regenerated neuromuscular junctions have junctional folds and accumulations of acetylcholine receptors and AChE

Sketch shows the paired cutaneous pectoris muscles with attached origin and insertion.

The muscle on the left is intact.

The nerve enters from the lateral edge.

Two rectangular areas have been cut from the muscle on the right, leaving behind a row of muscle fiber segments, a "bridge", between undamaged medial and lateral fibers.

In some experiments, a "foreign" nerve (arrow), which normally supplies the forelimb, was implanted near the bridge.

Bar, 3 mm.

Reference

<pubmed>307554</pubmed>

See also: Anglister L, McMahan UJ J Cell Biol 1985 Sep;101(3):735-43 PMC2117033

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Figure 1

Cite this page: Hill, M.A. (2024, April 27) Embryology Skeletal muscle basal lamina exp01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Skeletal_muscle_basal_lamina_exp01.jpg

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