File:Ovarian developmental genes.jpg

Ovarian Developmental Genes

Putative interactions among developmental genes inferred from the comparison of several knockout models of ovarian dysgenesis.

Arrows indicate positive interactions. Most cases of competitive or antagonistic interactions are not represented, because all genes except Sox9 and Dhh can be connected by (positive) arrows with at least an ovarian gene.

Sox9 and Dhh are not induced by any of the ovarian genes that have been functionally tested, and are antagonized specifically by Foxl2 and Wnt4. Color coding is purely indicative of overall gonadal expression and/or function (legend is at the bottom).

Note that inferences regarding direct or indirect regulatory biochemical interactions cannot be derived from this type of analysis: arrows only indicate the apparent requirement of a gene (to which the arrow points) for the function of another gene (from which the arrow originates) as assessed in knockout mice. This identifies a putative target-regulator connection.

Line thickness indicates the degree of statistical association between the putative target gene and the putative regulator.

Links: Ovary Development | Molecular Development | Sox

Reference

<pubmed>19538736</pubmed>| PMC2711087 | BMC Dev Biol.

Copyright

© 2009 Garcia-Ortiz et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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"Partial loss of function of the transcription factor FOXL2 leads to premature ovarian failure in women. In animal models, Foxl2 is required for maintenance, and possibly induction, of female sex determination independently of other critical genes, e.g., Rspo1. Here we report expression profiling of mouse ovaries that lack Foxl2 alone or in combination with Wnt4 or Kit/c-Kit."