File:Mouse tooth stem cell.png

Mouse tooth stem cell

(A) Basic overall organization of the incisor tooth. Growth occurs from proximal to apical (incisal) end. At the proximal end lie the lingual and labial cervical loops, each containing epithelial stem cells.

(B) Enlargement of boxed region in (A) showing the individual cell types that comprise the proximal end. Stem cells reside within stellate reticulum, core of the cervical loop. See text for details. Color coding is as follows: enamel (red), dentin (blue), epithelium (orange), and follicular mesenchyme (green).

DE, dental epithelium, FM, follicle mesenchyme, IDE, inner dental epithelium, ODE, outer dental epithelium, PM, papilla mesenchyme, SR, stellate reticulum, TA, transit amplifying.

http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.0050159

Citation: Wang X-P, Suomalainen M, Felszeghy S, Zelarayan LC, Alonso MT, et al. (2007) An Integrated Gene Regulatory Network Controls Stem Cell Proliferation in Teeth . PLoS Biol 5(6): e159. doi:10.1371/journal.pbio.0050159

Received: November 15, 2006; Accepted: April 13, 2007; Published: June 12, 2007

Copyright: © 2007 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.