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Mouse Eye TGF-beta Model

Summary of the TGFβ-dependent development of anterior and posterior ocular structures.
a Neural crest-derived cells (NC, blue) contribute to structures of the anterior eye segment and the primary vitreous (PV).
  • TGFβ signaling is involved in the formation of the ciliary body (CB) and the trabecular meshwork (TM), and in control of PV growth.
  • Moreover, normal PV development and/or TGFβ signaling are important for correct retinal patterning.
b In the cornea, prospective stromal keratocytes and endothelial cells are of neural crest origin.
  • Here, TGFβ signaling is needed for the expression of the transcription factors Foxc1 and Pitx2 and for normal differentiation of NC-derived cells into collagen-synthesizing stromal keratocytes.
  • Moreover, in forming corneal endothelial cells (and in the TM), expression of Foxc1 and cell survival requires TGFβ signalling.


Links: Image - Mouse eye neural crest | Image - Mouse eye TGF-beta model TGF-beta | Cornea Development | Vision Development | Neural Crest Development | Head Development


Reference

<pubmed>16403239</pubmed>| J Biol.

Copyright

© 2005 Ittner et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Ittner et al. Journal of Biology 2005 4:11 doi:10.1186/jbiol29

Original file name: Figure 9. http://jbiol.com/content/4/3/11/figure/F9

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current18:32, 30 August 2011Thumbnail for version as of 18:32, 30 August 20111,000 × 519 (88 KB)S8600021 (talk | contribs)==Mouse eye TGF-beta model== Summary of the TGFβ-dependent development of anterior and posterior ocular structures. (a) NC-derived cells (blue) contribute to structures of the anterior eye segment and the primary vitreous (PV). TGFβ signaling is invo
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