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Analysis of Mouse Stage E10.5 Specific Gene Expression

1140 transcripts were found to be significantly up-regulated exclusively at one developmental time point. A large fraction of these stage specific genes were found to be novel, in particular at E13.5 only 5% of the transcripts had confirmed musculoskeletal knockout phenotypes and 6% of the genes have been validated by in situ hybridization.


A survey of available in situ expression profiles for genes with peak expression levels at E10.5 revealed that they display a wide range of patterns, and include closely related members of gene families such as Irx, Smarc and zinc finger transcription factors.


Limb Links: Mouse limb skeleton cartoon | Mouse limb tissue development | Limb Development | Mouse Development
Gene Expression Patterns: E9.5 | E10.5 | E11.5 | E12.5 | E13.5 | Lmx1b | Forelimb | Tbx5 | Fbxo41 | Hoxc5 | Hoxb5 | Prdm1 | Hoxb6 | Etv2 | Egr1 | Figf | Sp6 | Cited1 | Prox1 | SmarcD2 | Echdc1 | Sim2 | Hindlimb | Tbx4 | Ptx1 | Hoxc10 | Hoxc9 | Dmrt2

Reference

Taher L, Collette NM, Murugesh D, Maxwell E, Ovcharenko I & Loots GG. (2011). Global gene expression analysis of murine limb development. PLoS ONE , 6, e28358. PMID: 22174793 DOI.

Copyright

This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

Figure 6. doi:10.1371/journal.pone.0028358.g006


Cite this page: Hill, M.A. (2019, April 22) Embryology Mouse E10.5 gene expression.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Mouse_E10.5_gene_expression.jpg

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© Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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