File:Model snRNP assembly in myeloma.jpg

Model of Small nuclear ribonucleic particle (snRNP) assembly in Myeloma

A schematic representation of the function and position of the MMSET gene and its products. MMSET II controls the di methylation on Lysine36 of Histone3 (2MeH3K36) and the tri methylation of Lysine 27 on histone3 (3MeH3K27) [9], [14]. Aca11 has been reported to be in the nucleolus [5], whilst the SMN complex has both cytoplasm and nucleus localization. The SMN complex is found in the nucleus at level of Cajal bodies or in the gem bodies. REIIBP and the SMN complex are likely to interact in the cytoplasm. REIIBP catalytic activity, possibly on the SMN complex, affects the number of spliceosome snRNPs particles causing splicing defects. The schematic representation of the SMN complex model is based on a previously proposed model [21]. The structures for REIIBP, ACA11, MMSET II and snRNPs are arbitrary.

Reference

<pubmed>24923560</pubmed>

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099493

Copyright

© 2014 Mirabella et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Figure 5 journal.pone.0099493.g005.jpg Panel cropped, resized and relabelled from original figure.

doi:10.1371/journal.pone.0099493.g005