File:Model of hypercoupled cytoskeleton.png

Acute loss of Gβ induces a hypercoupled cytoskeleton

By synchronizing weakly coupled peripheral oscillators, a hypercoupled state is induced that is apparent as whole-field oscillations. This pathologic state is less permissive to the establishment of cell polarity and continuous realignment of polarity in a gradient. We suggest that this hypercoupled state prevents oscillators from becoming patterned by upstream signaling cues from inside or outside the cell.

Reference

<pubmed>26890004</pubmed>

Copyright

© 2016 Hoeller et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

doi:10.1371/journal.pbio.1002381.g008Journal.pbio.1002381.g008.PNG

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